Mechanisms and molecular targets surrounding the potential therapeutic effects of psychedelics

AM Jaster, J González-Maeso - Molecular psychiatry, 2023 - nature.com
Psychedelics, also known as classical hallucinogens, have been investigated for decades
due to their potential therapeutic effects in the treatment of neuropsychiatric and substance …

Hallucinogens

DE Nichols - Pharmacology & therapeutics, 2004 - Elsevier
Hallucinogens (psychedelics) are psychoactive substances that powerfully alter perception,
mood, and a host of cognitive processes. They are considered physiologically safe and do …

Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase

R Zimmermann, JG Strauss, G Haemmerle… - Science, 2004 - science.org
Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic
enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the …

Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis

CS Tan, IJ Koralnik - The Lancet Neurology, 2010 - thelancet.com
Progressive multifocal leukoencephalopathy (PML) is a rare but often fatal brain disease
caused by reactivation of the polyomavirus JC. Knowledge of the characteristics of PML has …

Serotonin receptors

DE Nichols, CD Nichols - Chemical reviews, 2008 - ACS Publications
Serotonin, 5-hydroxytryptamine (5-HT), is one of the class of monoamine neurontransmitters,
all of which have a chemical template comprised of a basic amino group separated from an …

Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology

DA Shapiro, S Renock, E Arrington… - …, 2003 - nature.com
Atypical antipsychotic drugs have revolutionized the treatment of schizophrenia and related
disorders. The current clinically approved atypical antipsychotic drugs are characterized by …

Salvinorin A: a potent naturally occurring nonnitrogenous κ opioid selective agonist

BL Roth, K Baner, R Westkaemper… - Proceedings of the …, 2002 - National Acad Sciences
Salvia divinorum, whose main active ingredient is the neoclerodane diterpene Salvinorin A,
is a hallucinogenic plant in the mint family that has been used in traditional spiritual …

Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia

J Horacek, V Bubenikova-Valesova, M Kopecek… - CNS drugs, 2006 - Springer
Atypical antipsychotics have greatly enhanced the treatment of schizophrenia. The
mechanisms underlying the effectiveness and adverse effects of these drugs are, to date, not …

The human polyomavirus, JCV, uses serotonin receptors to infect cells

GF Elphick, W Querbes, JA Jordan, GV Gee, S Eash… - Science, 2004 - science.org
The human polyomavirus, JCV, causes the fatal demyelinating disease progressive
multifocal leukoencephalopathy in immunocompromised patients. We found that the …

Paradoxical trafficking and regulation of 5-HT2A receptors by agonists and antagonists

JA Gray, BL Roth - Brain research bulletin, 2001 - Elsevier
5-Hydroxytryptamine2A (serotonin2A, 5-HT2A) receptors are important for many physiologic
processes including platelet aggregation, smooth muscle contraction, and the modulation of …