Epigenetic alternations concern heritable yet reversible changes in histone or DNA
modifications that regulate gene activity beyond the underlying sequence. Epigenetic …

The occurrence of cancer entails a series of genetic mutations that favor uncontrollable
tumor growth. It is believed that various factors collectively contribute to cancer, and there is …

Iron metabolism and tumor biology are intimately linked. Iron facilitates the production of
oxygen radicals, which may either result in iron-induced cell death, ferroptosis, or contribute …

Apoptotic cells are rapidly engulfed and degraded by phagocytes through efferocytosis.
Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase …

Hypoxia is the major influence factor in physiological and pathological courses which are
mainly mediated by hypoxia-inducible factors (HIFs) in response to low oxygen tensions …

The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists
of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer …

The iron-and 2-oxoglutarate-dependent oxygenases constitute a phylogenetically
conserved class of enzymes that catalyze hydroxylation reactions in humans by acting on …

Protein arginine methylation is a common post-translational modification involved in
numerous cellular processes including transcription, DNA repair, mRNA splicing and signal …

Jumonji domain-containing 6 (JMJD6) is a member of the Jumonji C domain-containing
family of proteins. Compared to other members of the family, the cellular activity of JMJD6 is …

Arginine methylation of histones is one mechanism of epigenetic regulation in eukaryotic
cells. Methylarginines can also be found in non-histone proteins involved in various different …