Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

MicroRNAs (miRNAs) are short non-coding RNAs that inhibit the expression of target genes
by directly binding to their mRNAs. miRNAs are transcribed as precursor molecules, which …

Dicer has a key role in small RNA biogenesis, processing double-stranded RNAs
(dsRNAs),. Human DICER (hDICER, also known as DICER1) is specialized for cleaving …

MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and
translational repression by binding to the target mRNAs. Since it was discovered in 1993 …

MicroRNAs (miRNAs) are small RNA molecules, with their role in gene silencing and
translational repression by binding to target mRNAs. Since it was discovered in 1993 …

Osteosarcoma (OS) is one of the most common bone cancers that constantly affects
children, teenagers, and young adults. Numerous epigenetic elements, such as miRNAs …

Renal cell carcinoma (RCC) has the highest mortality rate of all genitourinary cancers, and
its prevalence has grown over time. While RCC can be surgically treated and recurrence is …

MicroRNA (miRNA) and RNA interference (RNAi) pathways rely on small RNAs produced by
Dicer endonucleases. Mammalian Dicer primarily supports the essential gene-regulating …

Small RNA molecules regulate eukaryotic gene expression during development and in
response to stresses including viral infection. Specialized ribonucleases and RNA-binding …

Dicer is central to microRNA-mediated silencing and several other RNA interference
phenomena that are profoundly embedded in cancer gene networks. Most recently, both …