[HTML][HTML] RNA granules in neuronal plasticity and disease

KE Bauer, BR de Queiroz, MA Kiebler, F Besse - Trends in Neurosciences, 2023 - cell.com
RNA granules are dynamic entities controlling the spatiotemporal distribution and translation
of RNA molecules. In neurons, a variety of RNA granules exist both in the soma and in …

Splicing regulation through biomolecular condensates and membraneless organelles

J Giudice, H Jiang - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Biomolecular condensates, sometimes also known as membraneless organelles (MLOs),
can form through weak multivalent intermolecular interactions of proteins and nucleic acids …

[HTML][HTML] Identification of small molecule inhibitors of G3BP-driven stress granule formation

BD Freibaum, J Messing, H Nakamura… - Journal of Cell …, 2024 - rupress.org
Stress granule formation is triggered by the release of mRNAs from polysomes and is
promoted by the action of the RNA-binding proteins G3BP1/2. Stress granules have been …

Global discovery of covalent modulators of ribonucleoprotein granules

AM Ciancone, KW Seo, M Chen, AL Borne… - Journal of the …, 2023 - ACS Publications
Stress granules (SGs) and processing-bodies (PBs, P-bodies) are ubiquitous and widely
studied ribonucleoprotein (RNP) granules involved in cellular stress response, viral …

[HTML][HTML] Macromolecular crowding is surprisingly unable to deform the structure of a model biomolecular condensate

JC Shillcock, DB Thomas, JH Ipsen, AD Brown - Biology, 2023 - mdpi.com
Simple Summary The cytoplasm of a living cell is a crowded place, containing hundreds of
types of protein and other macromolecules. Cells reliably and continually perform thousands …

[HTML][HTML] Refining the role of N6-methyladenosine in cancer

J Koch, F Lyko - Current Opinion in Genetics & Development, 2024 - Elsevier
N 6-methyladenosine (m 6 A) is the most abundant internal modification of eukaryotic
mRNAs. m 6 A affects the fate of its targets in all aspects of the mRNA life cycle and has …

Biomolecular condensates as novel antiviral targets

EW Martin, C Iserman, B Olety, DM Mitrea… - Journal of Molecular …, 2023 - Elsevier
Viral infections pose a significant health risk worldwide. There is a pressing need for more
effective antiviral drugs to combat emerging novel viruses and the reemergence of …

[HTML][HTML] It is theoretically possible to avoid misfolding into non-covalent lasso entanglements using small molecule drugs

Y Jiang, CM Deane, GM Morris… - PLoS computational …, 2024 - journals.plos.org
A novel class of protein misfolding characterized by either the formation of non-native
noncovalent lasso entanglements in the misfolded structure or loss of native entanglements …

[HTML][HTML] Secretory Phospholipases A2, from Snakebite Envenoming to a Myriad of Inflammation Associated Human Diseases—What Is the Secret of Their Activity?

F Tonello - International Journal of Molecular Sciences, 2023 - mdpi.com
Secreted phospholipases of type A2 (sPLA2s) are proteins of 14–16 kDa present in
mammals in different forms and at different body sites. They are involved in lipid …

[引用][C] SMALL-MOLECULE INTERACTIONS WITH BIOMOLECULAR CONDENSATES

GS Tria, JW Tucker, ME Spilker, BA Conti… - 2023 Medicinal …, 2023 - ACS Publications