Macrophage inflammatory protein-1α (MIP-1α) and MIP-1β are highly related members of
the CC chemokine subfamily. Despite their structural similarities, MIP-1α and MIP-1β show …

Natural peptides displaying agonist activity on the orphan G protein-coupled receptor
GPR54 were isolated from human placenta. These 54-, 14,-and 13-amino acid peptides …

The stromal cell-derived factor-1/CXCL12 chemokine engages the CXCR4 and CXCR7
receptors and regulates homeostatic and pathologic processes, including organogenesis …

Chemokines are the largest family of cytokines in human immunophysiology. These proteins
are defined by four invariant cysteines and are categorized based on the sequence around …

CC chemokine receptor 5 (CCR5) is a seven-transmembrane, G protein-coupled receptor
(GPCR) which regulates trafficking and effector functions of memory/effector T-lymphocytes …

CCR5 is the primary chemokine receptor utilized by HIV to infect leukocytes, whereas CCR5
ligands inhibit infection by blocking CCR5 engagement with HIV gp120. To guide the design …

When HIV was initially discovered as the causative agent of AIDS, many expected to find a
vaccine within a few years. This has however proven to be elusive; it has been …

This review focuses on the construction and application of structural chemokine receptor
models for the elucidation of molecular determinants of chemokine receptor modulation and …

CXCR4 is a G-coupled receptor for the stromal cell-derived factor (SDF-1) chemokine, and a
CD4-associated human immunodeficiency virus type 1 (HIV-1) coreceptor. These functions …

The internalization and intracellular trafficking of chemokine receptors have important
implications for the cellular responses elicited by chemokine receptors. The major pathway …