Platelet granules are unique among secretory vesicles in both their content and their life
cycle. Platelets contain three major granule types—dense granules, α-granules, and …

Human platelets arise as subcellular fragments of megakaryocytes in bone marrow. The
physiologic demand, presence of disease such as cancer, or drug effects can regulate the …

Some familial platelet disorders are associated with predisposition to leukemia,
myelodysplastic syndrome (MDS) or dyserythropoietic anemia,. We identified a family with …

Lysosome‐related organelles (LROs) comprise a diverse group of cell type‐specific,
membrane‐bound subcellular organelles that derive at least in part from the endolysosomal …

Abstract Human actin-related protein 2/3 complex (Arp2/3), required for actin filament
branching, has two ARPC1 component isoforms, with ARPC1B prominently expressed in …

Lysosome-related organelles (LROs) comprise a group of cell type-specific subcellular
compartments with unique composition, morphology and structure that share some features …

Platelets engage cues of pending vascular injury through coordinated adhesion, secretion,
and aggregation responses. These rapid, progressive changes in platelet form and function …

BEACH (named after 'Beige and Chediak‐Higashi') is a conserved∼ 280 residue domain,
present in nine human BEACH domain containing proteins (BDCPs). Most BDCPs are large …

Multisubunit tethering complexes (MTCs) are multitasking hubs that form a link between
membrane fusion, organelle motility and signaling. CORVET, CHEVI and HOPS are MTCs of …

The mammalian homotypic fusion and vacuole protein sorting (HOPS) complex is comprised
of six subunits: VPS11, VPS16, VPS18, VPS39, VPS41 and the Sec1/Munc18 (SM) family …