Acute pancreatitis is a common indication for hospital admission, increasing in incidence,
including in children, pregnancy and the elderly. Moderately severe acute pancreatitis with …

Pancreatic cancer is a devastating gastrointestinal cancer characterized by late diagnosis,
limited treatment success and dismal prognosis. Exocrine tumours account for 95% of …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the genus
Betacoronavirus within the family Coronaviridae. It is an enveloped single-stranded positive …

Almost all human diseases are strongly associated with inflammation, and a deep
understanding of the exact mechanism is helpful for treatment. The NLRP3 inflammasome …

Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Severe acute pancreatitis (SAP) is a critical illness characterized by a severe systemic
inflammatory response resulting in persistent multiple organ failure and sepsis. The …

Chronic pancreatitis is a multifactorial, fibroinflammatory syndrome in which repetitive
episodes of pancreatic inflammation lead to extensive fibrotic tissue replacement, resulting …

MCC950, an NLRP3 inflammasome inhibitor, displays multiple pharmacological properties.
However, the protective potential and underlying mechanism of MCC950 against …

Two years after the emergence of SARS-CoV-2, our understanding of COVID-19 disease
pathogenesis is still incomplete. Despite unprecedented global collaborative scientific efforts …

Early dysbiosis of the gut microbiota is associated with the severity of acute pancreatitis
(AP), although the underlying mechanism is unclear. Here, we investigated the role of …