Dopamine receptor subtypes, physiology and pharmacology: new ligands and concepts in schizophrenia
JC Martel, S Gatti McArthur - Frontiers in pharmacology, 2020 - frontiersin.org
Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …
modulator roles on motor functions, motivation and drive, as well as cognition. The …
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
[HTML][HTML] Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro imaging genetics through meta …
Background The profile of cortical neuroanatomical abnormalities in schizophrenia is not
fully understood, despite hundreds of published structural brain imaging studies. This study …
fully understood, despite hundreds of published structural brain imaging studies. This study …
Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis
Childhood neglect and/or abuse can induce mental health conditions with unknown
mechanisms. Here, we identified stress hormones as strong inducers of astrocyte-mediated …
mechanisms. Here, we identified stress hormones as strong inducers of astrocyte-mediated …
In vivo evidence of lower synaptic vesicle density in schizophrenia
Decreased synaptic spine density has been the most consistently reported postmortem
finding in schizophrenia (SCZ). A recently developed in vivo measure of synaptic vesicle …
finding in schizophrenia (SCZ). A recently developed in vivo measure of synaptic vesicle …
Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11. 2 deletion syndrome: a review of ENIGMA …
This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …
Individual-specific functional connectivity markers track dimensional and categorical features of psychotic illness
Neuroimaging studies of psychotic disorders have demonstrated abnormalities in structural
and functional connectivity involving widespread brain networks. However, these group …
and functional connectivity involving widespread brain networks. However, these group …
Could psychedelic drugs have a role in the treatment of schizophrenia? Rationale and strategy for safe implementation
Schizophrenia is a widespread psychiatric disorder that affects 0.5–1.0% of the world's
population and induces significant, long-term disability that exacts high personal and …
population and induces significant, long-term disability that exacts high personal and …
Derivation and utility of schizophrenia polygenic risk associated multimodal MRI frontotemporal network
Schizophrenia is a highly heritable psychiatric disorder characterized by widespread
functional and structural brain abnormalities. However, previous association studies …
functional and structural brain abnormalities. However, previous association studies …
Pathophysiology of negative symptom dimensions of schizophrenia–current developments and implications for treatment
Negative symptoms of schizophrenia comprise a group of severe symptoms contributing to
high disease burden and poor long-term prognosis. Conceptual work has shown that these …
high disease burden and poor long-term prognosis. Conceptual work has shown that these …