The NRF2, thioredoxin, and glutathione system in tumorigenesis and anticancer therapies
Cancer remains an elusive, highly complex disease and a global burden. Constant change
by acquired mutations and metabolic reprogramming contribute to the high inter-and …
by acquired mutations and metabolic reprogramming contribute to the high inter-and …
Thioredoxin-interacting protein (TXNIP) with focus on brain and neurodegenerative diseases
H Tsubaki, I Tooyama, DG Walker - International journal of molecular …, 2020 - mdpi.com
The development of new therapeutic approaches to diseases relies on the identification of
key molecular targets involved in amplifying disease processes. One such molecule is …
key molecular targets involved in amplifying disease processes. One such molecule is …
Bioorthogonal PROTAC prodrugs enabled by on-target activation
Although proteolysis targeting chimeras (PROTACs) have become promising therapeutic
modalities, important concerns exist about the potential toxicity of the approach owing to …
modalities, important concerns exist about the potential toxicity of the approach owing to …
The role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control
Thioredoxin-interacting protein (TXNIP) is commonly considered a master regulator of
cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent work …
cellular oxidation, regulating the expression and function of Thioredoxin (Trx). Recent work …
Salvia miltiorrhiza in diabetes: A review of its pharmacology, phytochemistry, and safety
Q Jia, R Zhu, Y Tian, B Chen, R Li, L Li, L Wang, Y Che… - Phytomedicine, 2019 - Elsevier
Background Salvia miltiorrhiza (SM), one of the frequently used herbs in traditional Chinese
medicine (TCM), has now attracted rising interests for a possible alternative in the …
medicine (TCM), has now attracted rising interests for a possible alternative in the …
[HTML][HTML] Identification of an anti-diabetic, orally available small molecule that regulates TXNIP expression and glucagon action
LA Thielen, J Chen, G Jing, O Moukha-Chafiq, G Xu… - Cell metabolism, 2020 - cell.com
Diabetes is characterized by hyperglycemia, loss of functional islet beta cell mass,
deficiency of glucose-lowering insulin, and persistent alpha cell secretion of gluconeogenic …
deficiency of glucose-lowering insulin, and persistent alpha cell secretion of gluconeogenic …
Macrophage migration inhibitory factor family proteins are multitasking cytokines in tissue injury
The family of macrophage migration inhibitory factor (MIF) proteins in humans consist of MIF,
its functional homolog D-dopachrome tautomerase (D-DT, also known as MIF-2) and the …
its functional homolog D-dopachrome tautomerase (D-DT, also known as MIF-2) and the …
Single-cell RNA transcriptome helps define the limbal/corneal epithelial stem/early transit amplifying cells and how autophagy affects this population
Purpose: Single-cell RNA-sequencing (scRNA-seq) was used to interrogate the relatively
rare stem (SC) and early transit amplifying (TA) cell populations in limbal/corneal epithelia …
rare stem (SC) and early transit amplifying (TA) cell populations in limbal/corneal epithelia …
Laron syndrome–a historical perspective
Abstract Laron Syndrome (LS)[OMIm# 262500], or primary GH insensitivity, was first
described in 1966 in consanguineous Jewish families from Yemen. LS is characterized by a …
described in 1966 in consanguineous Jewish families from Yemen. LS is characterized by a …
Focus on the role of mitochondria in NLRP3 inflammasome activation: A prospective target for the treatment of ischemic stroke
X Zhang, W Zeng, Y Zhang, Q Yu… - International …, 2022 - spandidos-publications.com
Post‑ischemic neuroinflammation induced by the innate local immune response is a major
pathophysiological feature of cerebral ischemic stroke, which remains the leading cause of …
pathophysiological feature of cerebral ischemic stroke, which remains the leading cause of …