Copper (Cu) is an essential trace element for all living organisms and used as cofactor in
key enzymes of important biological processes, such as aerobic respiration or superoxide …

In the past decade, evidence for the numerous roles of copper (Cu) in mammalian
physiology has grown exponentially. The discoveries of Cu involvement in cell signaling …

Among the biologically required first row, late d-block metals from Mn II to Zn II, the catalytic
and structural reach of Zn II ensures that this essential micronutrient touches nearly every …

Summary The P-type ATPase ATP7B exports cytosolic copper and plays an essential role in
the regulation of cellular copper homeostasis. Mutants of ATP7B cause Wilson disease …

Membrane trafficking pathways emanating from the Golgi regulate a wide range of cellular
processes. One of these is the maintenance of copper (Cu) homeostasis operated by the …

Fungal cells colonize and proliferate in distinct niches, from soil and plants to diverse tissues
in human hosts. Consequently, fungi are challenged with the goal of obtaining nutrients …

Functional characterization of transport proteins using conventional electrophysiology can
be challenging, especially for low turnover transporters or transporters from bacteria and …

Copper is essential for living cells, yet toxic at elevated concentrations. Class 1B P-type
(P1B-) ATPases are present in all kingdoms of life, facilitating cellular export of transition …

Metal clusters are exploited by numerous metalloenzymes for catalysis, but it is not common
to utilize a metal cluster for substrate transport across membrane. The recent crystal …

Transition metals function as structural and catalytic cofactors for a large diversity of proteins
and enzymes that collectively comprise the metalloproteome. Metallostasis considers all …