Giardiasis in the post genomic era: treatment, drug resistance and novel therapeutic perspectives

M Lalle - Infectious Disorders-Drug Targets (Formerly Current …, 2010 - ingentaconnect.com
Giardia duodenalis (syn. G. lamblia, G. intestinalis) is a flagellated protozoan, member of the
order Diplomonadidae, that parasitizes the upper part of the small intestine of mammals …

Carbonyl stress in red blood cells and hemoglobin

OV Kosmachevskaya, NN Novikova, AF Topunov - Antioxidants, 2021 - mdpi.com
The paper overviews the peculiarities of carbonyl stress in nucleus-free mammal red blood
cells (RBCs). Some functional features of RBCs make them exceptionally susceptible to …

Antimicrobial resistance of the enteric protozoon Giardia duodenalis – A narrative review

U Loderstädt, H Frickmann - European Journal of Microbiology and …, 2021 - akjournals.com
Introduction As therapy-refractory giardiasis is an emerging health issue, this review aimed
at summarizing mechanisms of reduced antimicrobial susceptibility in Giardia duodenalis …

Targeting the Warburg Effect in Cancer: Where Do We Stand?

I Barba, L Carrillo-Bosch, J Seoane - International Journal of Molecular …, 2024 - mdpi.com
The Warburg effect, characterized by the preferential conversion of glucose to lactate even
in the presence of oxygen and functional mitochondria, is a prominent metabolic hallmark of …

The stability of G6PD is affected by mutations with different clinical phenotypes

S Gómez-Manzo, J Terrón-Hernández… - International journal of …, 2014 - mdpi.com
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme
deficiency worldwide, causing a wide spectrum of conditions with severity classified from the …

Pyridyl Methylsulfinyl Benzimidazole Derivatives as Promising Agents against Giardia lamblia and Trichomonas vaginalis

B Hernández-Ochoa, V Martínez-Rosas… - Molecules, 2022 - mdpi.com
Protozoan parasites, such as Giardia lamblia and Trichomonas vaginalis, cause the most
prevalent infections in humans in developing countries and provoke significant morbidity …

Recent advances in the development of triose phosphate isomerase inhibitors as antiprotozoal agents

LK Vázquez-Jiménez, A Moreno-Herrera… - Current Medicinal …, 2022 - ingentaconnect.com
Background: Parasitic diseases caused by protozoa, such as Chagas disease,
leishmaniasis, malaria, African trypanosomiasis, amoebiasis, trichomoniasis, and giardiasis …

Pathomechanisms, therapeutic targets and potent inhibitors of some beta-coronaviruses from bench-to-bedside

YO Ayipo, SN Yahaya, WA Alananzeh… - Infection, Genetics and …, 2021 - Elsevier
Since the emergence of their primitive strains, the complexity surrounding their
pathogenesis, constant genetic mutation and translation are contributing factors to the …

On the molecular and cellular effects of omeprazole to further support its effectiveness as an antigiardial drug

G López-Velázquez, C Fernández-Lainez… - Scientific reports, 2019 - nature.com
Research on Giardia lamblia has accumulated large information about its molecular cell
biology and infection biology. However, giardiasis is still one of the commonest parasitic …

[HTML][HTML] Selective Inhibition of Deamidated Triosephosphate Isomerase by Disulfiram, Curcumin, and Sodium Dichloroacetate: Synergistic Therapeutic Strategies for T …

LA Flores-López, CM Malagón-Reyes… - …, 2024 - pmc.ncbi.nlm.nih.gov
T-cell acute lymphoblastic leukemia (T-ALL) is a challenging childhood cancer to treat, with
limited therapeutic options and high relapse rates. This study explores deamidated …