Cytokines and C-reactive protein alterations with respect to cognitive impairment in schizophrenia and bipolar disorder: a systematic review

B Misiak, B Stańczykiewicz, K Kotowicz… - Schizophrenia …, 2018 - Elsevier
Background The aim of this article was to perform a systematic review of studies
investigating the association between peripheral levels of cytokines and C-reactive protein …

Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far?

RSE Keefe, RW Buchanan, SR Marder… - Schizophrenia …, 2013 - academic.oup.com
In light of the number of studies conducted to examine the treatment of cognitive impairment
associated with schizophrenia (CIAS), we critically reviewed recent CIAS trials. Trials were …

Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction

M Ayalew, H Le-Niculescu, DF Levey, N Jain… - Molecular …, 2012 - nature.com
We have used a translational convergent functional genomics (CFG) approach to identify
and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide …

Pharmacogenetics of antipsychotics

EJ Brandl, JL Kennedy… - The Canadian Journal of …, 2014 - journals.sagepub.com
Objective: During the past decades, increasing efforts have been invested in studies to
unravel the influence of genetic factors on antipsychotic (AP) dosage, treatment response …

DNA methylation and antipsychotic treatment mechanisms in schizophrenia: Progress and future directions

ES Ovenden, NW McGregor, RA Emsley… - Progress in Neuro …, 2018 - Elsevier
Antipsychotic response in schizophrenia is a complex, multifactorial trait influenced by
pharmacogenetic factors. With genetic studies thus far providing little biological insight or …

Modifications of glycans: biological significance and therapeutic opportunities

SM Muthana, CT Campbell… - ACS chemical biology, 2012 - ACS Publications
Carbohydrates play a central role in a wide range of biological processes. As with nucleic
acids and proteins, modifications of specific sites within the glycan chain can modulate a …

Precision medicine approaches to mental health care

JJ Scala, AB Ganz, MP Snyder - Physiology, 2023 - journals.physiology.org
Developing a more comprehensive understanding of the physiological underpinnings of
mental illness, precision medicine has the potential to revolutionize psychiatric care. With …

Antipsychotic drug responsiveness and dopamine receptor signaling; old players and new prospects

A Rampino, A Marakhovskaia, T Soares-Silva… - Frontiers in …, 2019 - frontiersin.org
Antipsychotic drugs targeting dopamine neurotransmission are still the principal mean of
therapeutic intervention for schizophrenia. However, about one third of people do not …

Genetic predictors of antipsychotic response to lurasidone identified in a genome wide association study and by schizophrenia risk genes

J Li, A Yoshikawa, MD Brennan, TL Ramsey… - Schizophrenia …, 2018 - Elsevier
Biomarkers which predict response to atypical antipsychotic drugs (AAPDs) increases their
benefit/risk ratio. We sought to identify common variants in genes which predict response to …

Pharmacogenetics of response to antipsychotics in patients with schizophrenia

MJ Arranz, M Rivera, JC Munro - CNS drugs, 2011 - Springer
This review presents the findings of pharmacogenetic studies exploring the influence of
gene variants on antipsychotic treatment response, in terms of both symptom improvement …