The term'super-enhancer'has been used to describe groups of putative enhancers in close
genomic proximity with unusually high levels of Mediator binding, as measured by chromatin …

We have used homologous recombination in ES cells to engineer B cell-deficient mice that
are incapable of expressing endogenous immunoglobulin heavy and kappa light chain …

This unique book looks at the biology of aging from a fundamentally new perspective, one
based on evolutionary theory rather than traditional concepts which emphasize molecular …

Specific chromosomal translocations found in distinct neoplasms suggest that genes that
flank such breakpoints play a critical role in transformation. We have characterized the t (14; …

Epstein–Barr Virus (EBV) contributes to the development of lymphoid and epithelial
malignancies. While EBV's latent phase is more commonly associated with EBV-associated …

Abstract c-MYC is the prototype for oncogene activation by chromosomal translocation. In
contrast to the tightly regulated expression of c-myc in normal cells, c-myc is frequently …

The diagnostic category of Burkitt's lymphoma encompasses a closely related group of
aggressive B-cell tumors that includes sporadic, endemic, and human immunodeficiency …

Interleukin 6 (IL-6) has been suggested to be involved in the pathogenesis of polyclonal and
monoclonal plasma cell abnormalities. To address this possibility, transgenic mice carrying …

Burkitt lymphoma (BL) is an aggressive B-cell malignancy with endemic, sporadic and
immunodeficiency-associated variants. It has been known for many years that the …

Publisher Summary This chapter discusses normal c-myc gene regulation and abnormal c-
myc regulation in cancer cells. All normal c-myc transcription units are composed of three …