p53, a tumor suppressor protein, has been proven to regulate the cell cycle, apoptosis, and
DNA repair to prevent malignant transformation. MDM2 regulates activity of p53 and inhibits …

The p53-MDM2 pathway plays a crucial role regulating tumor suppression and is a focal
point of cancer research. This literature review delves into the complex interplay between …

Previously we have shown that among 15 substituted salicyloyl (2-hydroxybenzoyl) 5-
seleninic acids (SSAs) 4 compounds with longer side chains or a cyclohexyl group exhibit …

Protein fibrillation is a challenging issue in medicine, causing many diseases, and an
impediment to pharmaceutics and protein industry. Many chemicals, especially polyphenol …

Objective: To verify the chronic consumption of grape juice effects on weight, body mass
index (BMI), cognitive function and the peripheral levels of global histone H4 acetylation …

Окислительный стресс является одним из главных звеньев многих патологических
состояний; изучается роль активных форм кислорода (АФК) в формировании …

In their contribution Verma et al. propose a drastic anti-cancer effect of quercetin and
taxifolin based on molecular dynamics (MD) simulations of the MDM2-p53 protein complex …

Mycobacterium tuberculosis is the causative agent of tuberculosis and also co-exists of
tuberculosis with HIV infection in human beings. So far, there are drugs available in market …

Aberrant protein-protein interactions (PPIs) are found in many disease states. Consequently,
there is a need for PPI inhibitors for use as research tools and pharmaceutical lead …