A guide for the diagnosis of rare and undiagnosed disease: beyond the exome
Rare diseases affect 30 million people in the USA and more than 300–400 million
worldwide, often causing chronic illness, disability, and premature death. Traditional …
worldwide, often causing chronic illness, disability, and premature death. Traditional …
Computational principles and challenges in single-cell data integration
The development of single-cell multimodal assays provides a powerful tool for investigating
multiple dimensions of cellular heterogeneity, enabling new insights into development …
multiple dimensions of cellular heterogeneity, enabling new insights into development …
MicrobiomeAnalyst 2.0: comprehensive statistical, functional and integrative analysis of microbiome data
Microbiome studies have become routine in biomedical, agricultural and environmental
sciences with diverse aims, including diversity profiling, functional characterization, and …
sciences with diverse aims, including diversity profiling, functional characterization, and …
MOGONET integrates multi-omics data using graph convolutional networks allowing patient classification and biomarker identification
To fully utilize the advances in omics technologies and achieve a more comprehensive
understanding of human diseases, novel computational methods are required for integrative …
understanding of human diseases, novel computational methods are required for integrative …
State of the field in multi-omics research: from computational needs to data mining and sharing
Multi-omics, variously called integrated omics, pan-omics, and trans-omics, aims to combine
two or more omics data sets to aid in data analysis, visualization and interpretation to …
two or more omics data sets to aid in data analysis, visualization and interpretation to …
Artificial intelligence and machine learning‐aided drug discovery in central nervous system diseases: State‐of‐the‐arts and future directions
Neurological disorders significantly outnumber diseases in other therapeutic areas.
However, developing drugs for central nervous system (CNS) disorders remains the most …
However, developing drugs for central nervous system (CNS) disorders remains the most …
Guidelines for the use of flow cytometry and cell sorting in immunological studies
A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …
immunology and flow cytometry community. They provide the theory and key practical …
Machine learning for multi-omics data integration in cancer
Multi-omics data analysis is an important aspect of cancer molecular biology studies and
has led to ground-breaking discoveries. Many efforts have been made to develop machine …
has led to ground-breaking discoveries. Many efforts have been made to develop machine …
Mediterranean diet intervention in overweight and obese subjects lowers plasma cholesterol and causes changes in the gut microbiome and metabolome …
Objectives This study aimed to explore the effects of an isocaloric Mediterranean diet (MD)
intervention on metabolic health, gut microbiome and systemic metabolome in subjects with …
intervention on metabolic health, gut microbiome and systemic metabolome in subjects with …
[HTML][HTML] Network analysis methods for studying microbial communities: A mini review
MS Matchado, M Lauber, S Reitmeier… - Computational and …, 2021 - Elsevier
Microorganisms including bacteria, fungi, viruses, protists and archaea live as communities
in complex and contiguous environments. They engage in numerous inter-and intra …
in complex and contiguous environments. They engage in numerous inter-and intra …