Hippocampal sclerosis (HS) is a common pathology encountered in mesial temporal lobe
epilepsy (MTLE) as well as other epilepsy syndromes and in both surgical and post‐mortem …

Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …

Acute ischemic stroke and traumatic brain injury are a major cause of mortality and
morbidity. Due to the paucity of therapies, there is a pressing clinical demand for new …

The kallikrein-kinin system (KKS) is an intricate endogenous pathway involved in several
physiological and pathological cascades in the brain. Due to the pathological effects of …

Over the past decades, the immune responses have been suspected of participating in the
mechanisms for epilepsy. To assess the immune related pathway in temporal lobe epilepsy …

Immune mechanisms have been increasingly recognized in the pathogenesis of
hippocampal sclerosis (HS), but infiltration of cytotoxic T-cells and its pathological …

Kallikreins (KLKs) are a family of 15 secreted serine proteases with emerging roles in
neurologic diseases. To illuminate their contributions to the pathophysiology of spinal cord …

Cell signaling mediated by P2X7 receptors (P2X7R) has been suggested to be involved in
epileptogenesis, via modulation of intracellular calcium levels, excitotoxicity, activation of …

Prenatal alcohol exposure (PAE) impairs fetal development. Alcohol consumption was
shown to modulate the renin–angiotensin system (RAS). This study aimed to analyze the …

Temporal lobe epilepsy (TLE) is a chronic disease, characterized by severe and refractory
seizures, triggered in the hippocampus and/or amygdala, disrupting the blood–brain barrier …