Galangin attenuates chlorpyrifos-induced kidney injury by mitigating oxidative stress and inflammation and upregulating Nrf2 and farnesoid-X-receptor in rats

RS Alruhaimi, AF Ahmeda, OE Hussein… - Environmental …, 2024 - Elsevier
Chlorpyrifos (CPF) is a highly toxic commonly used pesticide and can seriously harm human
health. This study assessed the potential of galangin (GAL), an antioxidant flavonoid, to …

Galangin prevents gentamicin-induced nephrotoxicity by modulating oxidative damage, inflammation and apoptosis in rats

MH Abukhalil, Z Al-Alami, HAA Altaie… - Naunyn-Schmiedeberg's …, 2024 - Springer
The well-known antibiotic gentamicin (GEN) works well against a variety of pathogenic
bacteria, nevertheless its therapeutic use might be limited by the possibility of nephrotoxicity …

Farnesol prevents chlorpyrifos nephrotoxicity by modulating inflammatory mediators, Nrf2 and FXR and attenuating oxidative stress

RS Alruhaimi, MF Alotaibi, SM Alnasser… - Food and Chemical …, 2024 - Elsevier
Chlorpyrifos (CPF) is a broad-spectrum insecticide widely employed in agricultural field for
pest control. Exposure to CPF is associated with serious effects to the main organs …

Diallyl Disulfide Mitigates Cadmium Hepatotoxicity by Attenuating Oxidative Stress and TLR-4/NF-κB Signaling and Upregulating PPARγ

RS Alruhaimi, EHM Hassanein… - Frontiers in …, 2024 - e-space.mmu.ac.uk
Background: Heavy metals can cause serious health problems that affect different organs.
Cadmium (Cd) is an environmental contaminant known for its toxicological consequences …

New Insights on the potential therapeutic effects of glibenclamide and Obeticholic acid against Alloxan-Induced diabetes mellitus in rat model

AA Aboushouk, HM Saad, AH Rohiem… - International …, 2024 - Elsevier
Diabetes mellitus (DM) represents a highly prevalent metabolic disorder across the globe.
This study aimed to determine the ameliorative efficacy of glibenclamide (Gli) and …

LOX-induced tubulointerstitial fibrosis via the TGF-β/LOX/Snail axis in diabetic mice

Y Lu, H Li, M Chen, Y Lin, X Zhang - Journal of Translational Medicine, 2025 - Springer
Background The partial epithelial-mesenchymal transition (EMT) is emerging as a significant
mechanism in diabetic nephropathy (DN). LOX is a copper amine oxidase conventionally …

[HTML][HTML] Role of ginsenoside Rg1 as a PPAR-γ activator in protecting against manganese-induced hepatotoxicity: Insights into the TLR4/MyD88/MAPK signaling …

M Zhao, M Zhang, S Ni - Ecotoxicology and Environmental Safety, 2025 - Elsevier
This study investigates the protective effect of ginsenoside Rg1 against manganese (Mn)-
induced hepatotoxicity, highlighting its role as a PPAR-γ activator and its impact on …

The causal association between cardiovascular proteins and diabetic nephropathy: a Mendelian randomization study

J Wang, Q Ma - International Urology and Nephrology, 2025 - Springer
Purpose To clarify the causal association between cardiovascular proteins and diabetic
nephropathy (DN) in Europeans. Methods The large genome-wide association study data of …