The third edition of Flow Cytometry Guidelines provides the key aspects to consider when
performing flow cytometry experiments and includes comprehensive sections describing …

Autoimmune disease, caused by unwanted immune responses to self-antigens, affects
millions of people each year and poses a great social and economic burden to individuals …

Regulatory T cell (Treg) therapy is a promising approach to improve outcomes in
transplantation and autoimmunity. In conventional T cell therapy, chronic stimulation can …

The discovery of FOXP3+ regulatory T (Treg) cells as a distinct cell lineage with a central
role in regulating immune responses provided a deeper understanding of self-tolerance …

PD-1 is an inhibitory receptor in T cells, and antibodies that block its interaction with ligands
augment anti-tumor immune responses. The clinical potential of these agents is limited by …

Since their discovery, CD4+ CD25hiFOXP3hi regulatory T cells (Tregs) have been firmly
established as a critical cell type for regulating immune homeostasis through a plethora of …

Treg therapy holds promise as a potentially curative approach to establish immune
tolerance in transplantation and autoimmune disease. An outstanding question is whether …

Studies of the monogenic autoimmune disease immunodysregulation polyendocrinopathy
enteropathy X-linked syndrome (IPEX) have elucidated the essential function of the …

FOXP3 gene is a key transcription factor driving immune tolerance and its deficiency causes
immune dysregulation, polyendocrinopathy, enteropathy X‐linked syndrome (IPEX), a …

CAR (Chimeric Antigen Receptor) T-cell therapy has revolutionized the field of oncology in
recent years. This innovative shift in cancer treatment also provides the opportunity to …