Hirschsprung disease is a common cause of neonatal and infantile large gut obstruction. It is
characterised by varying extent of contiguous aganglionosis extending from the anorectum …

Background Hirschsprung's disease (HD) is one of the most common congenital anomalies
of colorectal function, affecting approximately 1 in 5000 live births, with a 4: 1 male …

Context.—In 2014, the College of American Pathologists developed an evidence-based
guideline to address analytic validation of immunohistochemical assays. Fourteen …

Background Immunohistochemistry (IHC) markers are employed to improve the diagnostic
yield when testing for Hirschsprung disease (HSCR). Yet, a superior test has not been …

Background: Hirschsprung disease is a complex genetic disorder of the enteric nervous
system (ENS), often called congenital aganglionic megacolon and characterized by the …

Introduction Rectal suction biopsy (RSB) is performed on clinical and radiological suspicion
of Hirschsprung disease (HD). Positive histochemical staining for acetylcholinesterase in the …

Background The study investigates the diagnostic value of calretinin immunohistochemical
staining (CIS) on rectal suction biopsies (RSB) in Hirschsprung's disease (HD). Methods A …

Background: Hirschsprung disease (HD) is diagnosed by absence of ganglion cells in rectal
biopsy. In some cases, standard methods fail to diagnose agangliosis. The aim of this study …

Background The reliability of intraoperative evaluation of ganglion cells in the appendix as a
guide to a diagnosis of total colonic aganglionosis is unclear. Objective To evaluate the …

BACKGROUND: Hirschsprung's disease (HD) is the major cause of pediatric intestinal
obstruction with a complex pattern of inheritance. The absence of ganglion cells along with …