Theranostic Nuclear Medicine with Gallium-68, Lutetium-177, Copper-64/67, Actinium-225, and Lead-212/203 Radionuclides: Focus Review

KA Morgan, SE Rudd, A Noor, PS Donnelly - Chemical Reviews, 2023 - ACS Publications
Molecular changes in malignant tissue can lead to an increase in the expression levels of
various proteins or receptors that can be used to target the disease. In oncology, diagnostic …

Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of disease

TJ Wadas, EH Wong, GR Weisman… - Chemical …, 2010 - ACS Publications
Molecular imaging is the visualization, characterization, and measurement of biological
processes at the molecular and cellular levels in humans and other living systems …

Copper-64 radiopharmaceuticals for PET imaging of cancer: advances in preclinical and clinical research

CJ Anderson, R Ferdani - Cancer Biotherapy and …, 2009 - liebertpub.com
Summation Copper-64 (T1/2= 12.7 hours; β+, 0.653 MeV [17.8%]; β−, 0.579 MeV [38.4%])
has decay characteristics that allow for positron emission tomography (PET) imaging and …

Biomedical applications of macrocyclic ligand complexes

RE Mewis, SJ Archibald - Coordination Chemistry Reviews, 2010 - Elsevier
Macrocyclic chelators can form highly stable complexes with transition metals and
lanthanides. In this review, the recent advances towards biomedical applications of …

Molecular imaging of cancer with copper-64 radiopharmaceuticals and positron emission tomography (PET)

M Shokeen, CJ Anderson - Accounts of chemical research, 2009 - ACS Publications
Molecular imaging has evolved over the past several years into an important tool for
diagnosing, understanding, and monitoring disease. Molecular imaging has distinguished …

Comparison of 64Cu-Complexing Bifunctional Chelators for Radioimmunoconjugation: Labeling Efficiency, Specific Activity, and in Vitro/in Vivo Stability

MS Cooper, MT Ma, K Sunassee, KP Shaw… - Bioconjugate …, 2012 - ACS Publications
High radiolabeling efficiency, preferably to high specific activity, and good stability of the
radioimmunoconjugate are essential features for a successful immunoconjugate for imaging …

89Zr, a Radiometal Nuclide with High Potential for Molecular Imaging with PET: Chemistry, Applications and Remaining Challenges

G Fischer, U Seibold, R Schirrmacher, B Wängler… - Molecules, 2013 - mdpi.com
Molecular imaging—and especially Positron Emission Tomography (PET)—is of increasing
importance for the diagnosis of various diseases and thus is experiencing increasing …

The role of coordination chemistry in the development of copper and rhenium radiopharmaceuticals

PS Donnelly - Dalton Transactions, 2011 - pubs.rsc.org
There are several isotopes of copper and rhenium that are of interest in the development of
new molecular imaging or radiotherapeutic agents. This perspective article highlights the …

Coordination chemistry of N-tetraalkylated cyclam ligands—A status report

EK Barefield - Coordination Chemistry Reviews, 2010 - Elsevier
N-alkylation of macrocyclic amines has a significant impact on their properties as ligands for
metal ions. This article examines the development of the coordination chemistry of N …

Development of novel PSMA ligands for imaging and therapy with copper isotopes

JC Dos Santos, B Beijer, U Bauder-Wüst… - Journal of Nuclear …, 2020 - Soc Nuclear Med
Prostate-specific membrane antigen (PSMA)–binding tracers have been shown to be
promising agents for the specific targeting of prostate tumors. On labeling with the short-lived …