Acute central nervous system injury, encompassing traumatic brain injury (TBI) and stroke,
accounts for a significant burden of morbidity and mortality worldwide. Studies in animal …

Despite the impressive efficacies demonstrated in preclinical research, hundreds of
potentially neuroprotective drugs have failed to provide effective neuroprotection for …

All attempts at treating strokes by pharmacologically reducing the human brain's
vulnerability to ischaemia have failed, leaving stroke as a leading cause of death, disability …

Despite the discovery of several promising neuroprotective therapies in rodent models of
stroke, no therapy other than the fibrinolytics has been found to be effective in human clinical …

Over decades, all attempts to translate acute stroke neuroprotectants from discovery in lower-
order species to human clinical use have failed. This raised concerns about the predictive …

The present review examines and discusses the changes in N‐acetylaspartate (NAA)
concentration in the ischaemic brain from the existing literature of animal research. By …

Objective. Ischemic lesion volume is assumed to be an important predictor of poststroke
neurological deficits and functional outcome. This critical review examines the …

Background and Purpose—We measured the temporal evolution of the T2 and diffusion
tensor imaging parameters after transient and permanent cerebral middle cerebral artery …

Tymianski Neuroprotection Trials With Endovascular Thrombectomy 1701 trial (Stroke–
Acute Ischemic NXY Treatment) received tPA. 15 Because recanalization within 6 hours of …

Over decades of research into the treatment of stroke, nearly all attempts to translate
experimental treatments from discovery in cells and rodents to use in humans have failed …