K+ channels play critical roles in a wide variety of physiological processes, including the
regulation of heart rate, muscle contraction, neurotransmitter release, neuronal excitability …

The Tenth Edition of the Handbook of Clinical Drug Data continues a long tradition of
providing clinically relevant, well-referenced drug information compiled by expert clinicians …

With β-blockers as the exception, increasing doubt is emerging on the value of
antiarrhythmic drug therapy following a series of trials that have either shown no mortality …

Since current experimental models of Atrial Fibrillation (AF) have significant limitations, we
used human embryonic stem cells (hESCs) to generate an atrial-specific tissue model of AF …

Background and purpose: Assessing the proarrhythmic potential of compounds during drug
development is essential. However, reliable prediction of drug‐induced torsades de pointes …

Cardiac safety remains the leading cause of drug development discontinuation. We
developed a human cardiomyocyte-based model that has the potential to provide a …

The aim of this study was to identify predictors of torsades de pointes (TdP) in patients with
atrial fibrillation (AF) or flutter exposed to the Class III antiarrhythmic drug almokalant. TdP …

Species and Drug‐Induced Long APD and EADs. Introduction: Although isolated Purkinje
fibers (PFs) often are used to evaluate the electrophysiologic effects of new drugs in terms of …

Background This study was designed to assess the efficacy and safety of intravenous
dofetilide in acute termination of atrial fibrillation (AF) and flutter (AFL). Dofetilide, an …

The effects of the two isomers,(+)-S 16257 and (−)-S 16260, of a new bradycardic agent,(±)-
S 15544 (7, 8-dimethoxy 3-{3-{[(4, 5-dimethoxybenzocyclobutan-1-yl) methyl] methylamino} …