The Notch signalling cascade is an evolutionarily conserved pathway that has a crucial role
in regulating development and homeostasis in various tissues. The cellular processes and …

Non-melanoma skin cancers are cutaneous malignancies representing the most common
form of cancer in the United States. They are comprised predominantly of basal cell …

Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently
lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome …

Epithelial-mesenchymal transition (EMT) is a physiological process that plays important
roles in tumor metastasis," stemness," and drug resistance. EMT is typically characterized by …

Squamous cell carcinoma (SCC) is an aggressive malignancy that can originate from
various organs. TP63 is a master regulator that plays an essential role in epidermal …

Squamous cell carcinoma (SCC) is a treatment‐refractory tumour which arises from the
epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin …

The tumor suppressor p53 homologues, TA-p73, and p63 have been shown to function as
tumor suppressors. However, how they function as tumor suppressors remains elusive …

Abstract p63, more specifically its ΔNp63α isoform, plays essential roles in squamous cell
carcinomas (SCC s), yet the mechanisms controlling its nuclear transport remain unknown …

The transcription factor p63 has important functions in tumorigenesis, epidermal
differentiation and stem cell self-renewal. The TP63 gene encodes multiple protein isoforms …

Purpose: Head and neck squamous cell carcinoma (HNSCC), a common cancer worldwide,
is etiologically associated with tobacco use, high alcohol consumption, and high-risk human …