The Wnt/β-catenin signaling pathway has been implicated as the central mechanism that
drives colorectal carcinogenesis. Its activation is historically due to mutation on APC …

Abstract β-catenin is the key transducer of the canonical Wnt signaling. Aberrant activation of
β-catenin has been tightly connected to the initiation and progression of various cancers …

Proximity biotinylation workflows typically require CRISPR-based genetic manipulation of
target cells. To overcome this bottleneck, we fused the TurboID proximity biotinylation …

Transcription factors are a group of proteins, which possess DNA-binding domains, bind to
DNA strands of promoters or enhancers, and initiate transcription of genes with cooperation …

Despite colorectal cancer remaining a leading worldwide cause of cancer-related death,
there remains a paucity of effective treatments for advanced disease. The molecular …

Irinotecan (CPT11) is one of the most effective drugs for treating colon cancer, but its severe
side effects limit its application. Recently, a traditional Chinese herbal preparation, named …

Eya1 is critical for establishing and maintaining nephron progenitor cells (NPCs). It belongs
to a family of proteins called phosphatase-transcriptional activators but without intrinsic DNA …

Tumour-promoting inflammation is involved in colorectal cancer (CRC) development and
therapeutic resistance. However, the antibiotics and antibacterial drugs and signalling that …

Human T-cell lymphotropic virus type 1 (HTLV-1) infection affects millions of individuals
worldwide and can lead to severe leukemia, myelopathy/tropical spastic paraparesis, and …

Despite decades of basic and clinical research and trials of promising new therapies, cancer
remains a major cause of morbidity and mortality due to the emergence of drug resistance to …