Mechanisms of epigenetic regulation, including DNA methylation, chromatin remodeling,
and histone post-translational modifications, are involved in multiple aspects of neuronal …

Chromatin is organized into higher-order structures that form subcompartments in
interphase nuclei. Different categories of specialized enzymes act on chromatin and …

The integrity of our genetic material is under constant attack from numerous endogenous
and exogenous agents. The consequences of a defective DNA damage response are well …

Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …

Chromium (Cr) is a naturally occurring metallic element found in the Earth's crust. While
trivalent chromium ([Cr (III)] is considered non-carcinogenic, hexavalent chromium [Cr (VI)] …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

The nuclear receptor PPARγ is a master regulator of adipogenesis. PPARγ is highly
expressed in adipose tissues and its expression is markedly induced during adipogenesis …

The maintenance of genome integrity is essential for organism survival and for the
inheritance of traits to offspring. Genomic instability is caused by DNA damage, aberrant …

Post-translational modification of histones provides an important regulatory platform for
processes such as gene expression, DNA replication and repair, chromosome condensation …

Dosage compensation is an epigenetic mechanism that normalizes gene expression from
unequal copy numbers of sex chromosomes. Different organisms have evolved alternative …