Immunotherapies for hepatocellular carcinoma
JM Llovet, F Castet, M Heikenwalder… - Nature reviews Clinical …, 2022 - nature.com
Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading
cause of cancer-related death and its incidence is increasing globally. Around 50% of …
cause of cancer-related death and its incidence is increasing globally. Around 50% of …
'Off-the-shelf'allogeneic CAR T cells: development and challenges
Autologous chimeric antigen receptor (CAR) T cells have changed the therapeutic
landscape in haematological malignancies. Nevertheless, the use of allogeneic CAR T cells …
landscape in haematological malignancies. Nevertheless, the use of allogeneic CAR T cells …
[HTML][HTML] Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses
KL Banta, X Xu, AS Chitre, A Au-Yeung, C Takahashi… - Immunity, 2022 - cell.com
Dual blockade of the PD-1 and TIGIT coinhibitory receptors on T cells shows promising early
results in cancer patients. Here, we studied the mechanisms whereby PD-1 and/or TIGIT …
results in cancer patients. Here, we studied the mechanisms whereby PD-1 and/or TIGIT …
Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has high relapse and low 5-year survival rates. Single-cell
profiling in relapsed HCC may aid in the design of effective anticancer therapies, including …
profiling in relapsed HCC may aid in the design of effective anticancer therapies, including …
The interaction of CD4+ helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response
Despite their key regulatory role and therapeutic potency, the molecular signatures of
interactions between T cells and antigen-presenting myeloid cells within the tumor …
interactions between T cells and antigen-presenting myeloid cells within the tumor …
The evolving role of tissue-resident memory T cells in infections and cancer
S Yenyuwadee, JL Sanchez-Trincado Lopez… - Science …, 2022 - science.org
Resident memory T cells (TRM) form a distinct type of T memory cells that stably resides in
tissues. TRM form an integral part of the immune sensing network and have the ability to …
tissues. TRM form an integral part of the immune sensing network and have the ability to …
Turning the corner on therapeutic cancer vaccines
RE Hollingsworth, K Jansen - npj Vaccines, 2019 - nature.com
Recent advances in several areas are rekindling interest and enabling progress in the
development of therapeutic cancer vaccines. These advances have been made in target …
development of therapeutic cancer vaccines. These advances have been made in target …
A dual‐responsive STAT3 inhibitor nanoprodrug combined with oncolytic virus elicits synergistic antitumor immune responses by igniting pyroptosis
W Su, W Qiu, SJ Li, S Wang, J Xie, QC Yang… - Advanced …, 2023 - Wiley Online Library
Immune checkpoint blockade (ICB) therapy shows excellent efficacy against malignancies;
however, insufficient tumor immunogenicity and the immunosuppressive tumor …
however, insufficient tumor immunogenicity and the immunosuppressive tumor …
Stem-like exhausted and memory CD8+ T cells in cancer
T Gebhardt, SL Park, IA Parish - Nature Reviews Cancer, 2023 - nature.com
T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …
extreme ends of this continuum are short-lived cells equipped with effector machinery and …
Helper T cell differentiation
CD4+ T helper cells are key regulators of host health and disease. In the original model,
specialized subsets of T helper cells are generated following activation through lineage …
specialized subsets of T helper cells are generated following activation through lineage …