Evaluating medical device and material thrombosis under flow: current and emerging technologies
Although blood-contacting medical devices are used widely, blood clot formation
(thrombosis) leads to device failure and potentially catastrophic adverse thrombotic events …
(thrombosis) leads to device failure and potentially catastrophic adverse thrombotic events …
The platelet shape change: biophysical basis and physiological consequences
AE Moskalensky, AL Litvinenko - Platelets, 2019 - Taylor & Francis
The well-known platelet shape change is the universal hallmark of activation. This review
uncovers the biophysics underlying this rapid and dramatic transformation. We aim to give a …
uncovers the biophysics underlying this rapid and dramatic transformation. We aim to give a …
Digital blood in massively parallel CPU/GPU systems for the study of platelet transport
C Kotsalos, J Latt, J Beny, B Chopard - Interface Focus, 2021 - royalsocietypublishing.org
We propose a highly versatile computational framework for the simulation of cellular blood
flow focusing on extreme performance without compromising accuracy or complexity. The …
flow focusing on extreme performance without compromising accuracy or complexity. The …
Novel stenotic microchannels to study thrombus formation in shear gradients: influence of shear forces and human platelet-related factors
Thrombus formation in hemostasis or thrombotic disease is initiated by the rapid adhesion,
activation, and aggregation of circulating platelets in flowing blood. At arterial or pathological …
activation, and aggregation of circulating platelets in flowing blood. At arterial or pathological …
Review of in silico models of cerebral blood flow in health and pathology
In this review, we provide a summary of the state-of-the-art in the in silico modelling of
cerebral blood flow (CBF) and its application in in silico clinical trials. CBF plays a key role in …
cerebral blood flow (CBF) and its application in in silico clinical trials. CBF plays a key role in …
Characterization of red blood cells agglutination based on stochastic collision electrochemical technique
Hemagglutination assays are important for blood group typing, alloantibodies screening and
biomarkers detecting. Simple and sensitive approach for both detecting and quantifying …
biomarkers detecting. Simple and sensitive approach for both detecting and quantifying …
Lattice Boltzmann method for modelling of biological phenomena
This paper suggests a new methodology based on the Lattice Boltzmann Method for the
modelling of complex biomechanical systems. The LBM can be applied for different …
modelling of complex biomechanical systems. The LBM can be applied for different …
Spherization of red blood cells and platelet margination in COPD patients
K Zouaoui Boudjeltia, C Kotsalos… - Annals of the New …, 2021 - Wiley Online Library
Red blood cells (RBCs) in pathological situations undergo biochemical and conformational
changes, leading to alterations in rheology involved in cardiovascular events. The shape of …
changes, leading to alterations in rheology involved in cardiovascular events. The shape of …
Modeling sensitivity and uncertainties in platelet activation models applied on centrifugal pumps for extracorporeal life support
G Fuchs, N Berg, LM Broman, L Prahl Wittberg - Scientific reports, 2019 - nature.com
Two platelet activation models were studied with respect to uncertainties of model
parameters and variables. The sensitivity was assessed using two direct/deterministic …
parameters and variables. The sensitivity was assessed using two direct/deterministic …
Shear induced diffusion of platelets revisited
The transport of platelets in blood is commonly assumed to obey an advection-diffusion
equation with a diffusion constant given by the so-called Zydney-Colton theory. Here we …
equation with a diffusion constant given by the so-called Zydney-Colton theory. Here we …