Neurons: the interplay between cytoskeleton, ion channels/transporters and mitochondria
Neurons are permanent cells whose key feature is information transmission via chemical
and electrical signals. Therefore, a finely tuned homeostasis is necessary to maintain …
and electrical signals. Therefore, a finely tuned homeostasis is necessary to maintain …
MFN2 deficiency impairs mitochondrial transport and downregulates motor protein expression in human spinal motor neurons
Charcot-Marie-Tooth (CMT) disease is one of the most common genetically inherited
neurological disorders and CMT type 2A (CMT 2A) is caused by dominant mutations in the …
neurological disorders and CMT type 2A (CMT 2A) is caused by dominant mutations in the …
[HTML][HTML] Liver-X-receptor agonists rescue axonal degeneration in SPG11-deficient neurons via regulating cholesterol trafficking
Abstract Spastic paraplegia type 11 (SPG11) is a common autosomal recessive form of
hereditary spastic paraplegia (HSP) characterized by the degeneration of cortical motor …
hereditary spastic paraplegia (HSP) characterized by the degeneration of cortical motor …
Expanding the Toolkit for In Vivo Imaging of Axonal Transport
Axonal transport maintains neuronal homeostasis by enabling the bidirectional trafficking of
diverse organelles and cargoes. Disruptions in axonal transport have devastating …
diverse organelles and cargoes. Disruptions in axonal transport have devastating …
Inhibiting mitochondrial fission rescues degeneration in hereditary spastic paraplegia neurons
Hereditary spastic paraplegias are characterized by lower limb spasticity resulting from
degeneration of long corticospinal axons. SPG11 is one of the most common autosomal …
degeneration of long corticospinal axons. SPG11 is one of the most common autosomal …
Impaired lipid metabolism in astrocytes underlies degeneration of cortical projection neurons in hereditary spastic paraplegia
Hereditary spastic paraplegias (HSPs) are caused by a length-dependent axonopathy of
long corticospinal neurons, but how axons of these cortical projection neurons (PNs) …
long corticospinal neurons, but how axons of these cortical projection neurons (PNs) …
[HTML][HTML] Lotus germ extract rejuvenates aging fibroblasts via restoration of disrupted proteostasis by the induction of autophagy
K Machihara, S Kageyama, S Oki, H Makino… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Cell aging attenuates cellular functions, resulting in time-dependent disruption of cellular
homeostasis, which maintains the functions of proteins and organelles. Mitochondria are …
homeostasis, which maintains the functions of proteins and organelles. Mitochondria are …
Multi-omics analysis of Bacillus. subtilis spores formed at different environmental temperatures reveal differences at the morphological and molecular level
Spore-forming bacteria play an essential role in the food industry and public health. Through
sporulation, bacteria can withstand extreme environmental conditions that vegetative cells …
sporulation, bacteria can withstand extreme environmental conditions that vegetative cells …