Long or short? Telomere length and pancreatic cancer and its precursor lesions, a narrative review

D Campa, A Felici, C Corradi, G Peduzzi… - …, 2023 - academic.oup.com
Pancreatic ductal adenocarcinoma (PDAC) is the most common and lethal form of
pancreatic cancer, with a survival approaching only 11% at five years after diagnosis. In the …

Multi-omic markers of Intraductal Papillary Mucinous Neoplasms progression into pancreatic cancer

C Corradi, M Gentiluomo, V Adsay, J Sainz… - Seminars in Cancer …, 2024 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is the most lethal and common form of
pancreatic cancer, it has no specific symptoms, and most of the patients are diagnosed …

Role of pancreatic ductal adenocarcinoma risk factors in intraductal papillary mucinous neoplasm progression

M Gentiluomo, C Corradi, PG Arcidiacono… - Frontiers in …, 2023 - frontiersin.org
Introduction Pancreatic ductal adenocarcinoma (PDAC) is lethal due to its late diagnosis
and lack of successful treatments. A possible strategy to reduce its death burden is …

[HTML][HTML] Analysis of exposome and genetic variability suggests stress as a major contributor for development of pancreatic ductal adenocarcinoma

G Peduzzi, A Felici, R Pellungrini, F Giorgolo… - Digestive and Liver …, 2024 - Elsevier
Background The current knowledge on pancreatic ductal adenocarcinoma (PDAC) risk
factors is limited and no study has comprehensively tested the exposome in combination …

A scan of all coding region variants of the human genome, identifies 13q12. 2-rs9579139 and 15q24. 1-rs2277598 as novel risk loci for pancreatic ductal …

M Giaccherini, L Gori, M Gentiluomo… - …, 2023 - academic.oup.com
Coding sequence variants comprise a small fraction of the germline genetic variability of the
human genome. However, they often cause deleterious change in protein function and are …

Explainable machine learning identifies a polygenic risk score as a key predictor of pancreatic cancer risk in the UK Biobank

G Peduzzi, A Felici, R Pellungrini, D Campa - Digestive and Liver Disease, 2024 - Elsevier
Background Predicting the risk of developing pancreatic ductal adenocarcinoma (PDAC) is
of paramount importance, given its high mortality rate. Current PDAC risk prediction models …

Polymorphisms within autophagy‐related genes as susceptibility biomarkers for pancreatic cancer: A meta‐analysis of three large European cohorts and functional …

F Gálvez‐Montosa, G Peduzzi… - … journal of cancer, 2025 - Wiley Online Library
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers with patients
having unresectable or metastatic disease at diagnosis, with poor prognosis and very short …

Physical Activity, Sedentary Behavior, and Pancreatic Cancer Risk: A Mendelian Randomization Study

M Gentiluomo, SC Dixon-Suen… - Journal of the …, 2024 - academic.oup.com
Pancreatic cancer is currently the seventh leading cause of cancer death worldwide.
Understanding whether modifiable factors increase or decrease the risk of this disease is …

Exploring the Neandertal legacy of pancreatic ductal adenocarcinoma risk in Eurasians

M Piccardi, M Gentiluomo, S Bertoncini, R Pezzilli… - Biological Research, 2023 - Springer
Background The genomes of present-day non-Africans are composed of 1–3% of
Neandertal-derived DNA as a consequence of admixture events between Neandertals and …

Dysbiosis Signature of Fecal Microbiota in Patients with Pancreatic Adenocarcinoma and Pancreatic Intraductal Papillary Mucinous Neoplasms

T Sidiropoulos, N Dovrolis, H Katifelis… - Biomedicines, 2024 - mdpi.com
Pancreatic cancer (PC) ranks as the seventh leading cause of cancer-related deaths, with
approximately 500,000 new cases reported in 2020. Existing strategies for early PC …