Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49624232&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49624232&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
The present disclosure provides a DNA-targeting RNA that comprises a targeting sequence
and, together with a modifying polypeptide, provides for site-specific modification of a target …
and, together with a modifying polypeptide, provides for site-specific modification of a target …
Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
JK Joung, JD Sander, M Maeder, Y Fu - US Patent 9,567,604, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
51537665&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
51537665&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Using RNA-guided FokI nucleases (RFNs) to increase specificity for RNA-guided genome editing
JK Joung, S Tsai - US Patent 9,567,603, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
51537665&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
51537665&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Increasing specificity for RNA-guided genome editing
JK Joung, J Angstman, JD Sander, M Maeder… - US Patent …, 2018 - Google Patents
US9885033B2 - Increasing specificity for RNA-guided genome editing - Google Patents
US9885033B2 - Increasing specificity for RNA-guided genome editing - Google Patents …
US9885033B2 - Increasing specificity for RNA-guided genome editing - Google Patents …
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
JK Joung, M Maeder - US Patent 10,760,064, 2020 - Google Patents
BACKGROUND Clustered Regulatory Interspaced Short Palindromic Repeats (CRISPR),
and CRISPR-associated (cas) genes, referred to as CRISPR/Cas systems, are used by …
and CRISPR-associated (cas) genes, referred to as CRISPR/Cas systems, are used by …
Using truncated guide RNAs (tru-gRNAs) to increase specificity for RNA-guided genome editing
JK Joung, JD Sander, Y Fu, M Maeder - US Patent 10,119,133, 2018 - Google Patents
CRISPR-Cas genome editing uses a guide RNA, which includes both a complementarity
region, which binds the target DNA by base-pairing, and a Cas9-binding region, to direct a …
region, which binds the target DNA by base-pairing, and a Cas9-binding region, to direct a …
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
JK Joung, M Maeder - US Patent 10,378,027, 2019 - Google Patents
US10378027B2 - RNA-guided targeting of genetic and epigenomic regulatory proteins to
specific genomic loci - Google Patents US10378027B2 - RNA-guided targeting of genetic …
specific genomic loci - Google Patents US10378027B2 - RNA-guided targeting of genetic …
Engineered CRISPR-Cas9 nucleases
JK Joung, B Kleinstiver, V Pattanayak - US Patent 9,512,446, 2016 - Google Patents
4,603,044 A 7, 1986 Geho et al. 4,957,773. A 9/1990 Spencer et al. 5,436,150 A 7, 1995
Chandrasegaran 6,007,988 A 12/1999 Choo et al. 6,013,453 A 1/2000 Choo et al …
Chandrasegaran 6,007,988 A 12/1999 Choo et al. 6,013,453 A 1/2000 Choo et al …
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49624232&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
49624232&utm_source= google_patent&utm_medium= platform_link&utm_campaign …