The simplest cell-like structure, the lipid bilayer vesicle, can respond to mechanical
deformation by elastic membrane dilation/thinning and curvature changes. When a protein is …

Cell death and dysfunction after traumatic brain injury (TBI) is caused by a primary phase,
related to direct mechanical disruption of the brain, and a secondary phase which consists of …

Diffuse axonal injury (DAI) is one of the most common and important pathologies resulting
from the mechanical deformation of the brain during trauma. It has been hypothesized that …

Voltage-gated sodium channels are glycoprotein complexes responsible for initiation and
propagation of action potentials in excitable cells such as central and peripheral neurons …

Traumatic brain injury (TBI) is distinct from other neurological disorders because it is
induced by a discrete event that applies extreme mechanical forces to the brain. This review …

Mibefradil is a tetralol derivative chemically distinct from other calcium channel antagonists.
It is a very effective antihypertensive agent that is thought to achieve its action via a higher …

The voltage‐sensitive sodium channel Nav1. 5 (encoded by SCN5A) is expressed in
electromechanical organs and is mechanosensitive. This study aimed to determine the …

Voltage-gated sodium channels (Nav) are modulated by many bilayer mechanical
amphiphiles, but whether, like other voltage-gated channels (Kv, HCN, Cav), they respond to …

Voltage-dependent K+ (Kv) channels underlie action potentials through gating
conformational changes that are driven by membrane voltage. In this study of the paddle …

Na+ channel recovery from inactivation limits the maximal rate of neuronal firing. However,
the properties of presynaptic Na+ channels are not well established because of the small …