Recent progress in engineering highly promising biocatalysts has increasingly involved
machine learning methods. These methods leverage existing experimental and simulation …

Natural proteins are often only slightly more stable in the native state than the denatured
state, and an increase in environmental temperature can easily shift the balance toward …

Protein evolution or engineering studies are traditionally focused on amino acid
substitutions and the way these contribute to fitness. Meanwhile, the insertion and deletion …

The cytochrome P450 family 1 enzymes (CYP1s) are a diverse family of hemoprotein
monooxygenases, which metabolize many xenobiotics including numerous environmental …

Many adhesion proteins, evolutionarily related through gene duplication, exhibit distinct and
precise interaction preferences and affinities crucial for cell patterning. Yet, the evolutionary …

Loops are small secondary structural elements that play a crucial role in the emergence of
new enzyme functions. However, the evolutionary molecular mechanisms how proteins …

Enzymes are biocatalysts capable of catalyzing reactions under environmentally friendly
conditions and can be applied in a wide variety of applications. However, biocatalysts are …

Insertions and deletions (indels) play a significant role in genome evolution across species.
Realistic modelling of indel evolution is challenging and is still an open research question …

The study of evolution is limited by the techniques available to do so. Aside from the use of
the fossil record, molecular phylogenetics can provide a detailed characterization of …

Loops are small secondary structural elements that play a crucial role in the emergence of
new enzyme functions. However, the evolutionary molecular mechanisms how proteins …