Innate immunity in tuberculosis: host defense vs pathogen evasion

CH Liu, H Liu, B Ge - Cellular & molecular immunology, 2017 - nature.com
The major innate immune cell types involved in tuberculosis (TB) infection are
macrophages, dendritic cells (DCs), neutrophils and natural killer (NK) cells. These immune …

Protein neddylation and its role in health and diseases

S Zhang, Q Yu, Z Li, Y Zhao, Y Sun - Signal Transduction and Targeted …, 2024 - nature.com
NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Diverse and pivotal roles of neddylation in metabolism and immunity

T Zou, J Zhang - The FEBS Journal, 2021 - Wiley Online Library
Neddylation is one type of protein post‐translational modification by conjugating a ubiquitin‐
like protein neural precursor cell‐expressed developmentally downregulated protein 8 to …

Neddylation regulation of immune responses

H Mao, X Lin, Y Sun - Research, 2023 - spj.science.org
Neddylation plays a vital role in post-translational modification, intricately shaping the
regulation of diverse biological processes, including those related to cellular immune …

Association between neddylation and immune response

J Zhu, F Chu, M Zhang, W Sun, F Zhou - Frontiers in Cell and …, 2022 - frontiersin.org
Neddylation is a ubiquitin-like post-translational protein modification. It occurs via the
activation of the neural precursor cell expressed, developmentally downregulated protein 8 …

Mycobacteria modulate SUMOylation to suppresses protective responses in dendritic cells

V Anang, A Singh, A Kumar Rana, SSK Saraswati… - Plos one, 2023 - journals.plos.org
Post translational modifications (PTMs) are exploited by various pathogens in order to
escape host immune responses. SUMOylation is one of the PTMs which is involved in …

[HTML][HTML] Inhibition of neddylation pathway represses influenza virus replication and pro-inflammatory responses

H Sun, W Yao, K Wang, Y Qian, H Chen, YS Jung - Virology, 2018 - Elsevier
The neddylation pathway belongs post-translational modifications and plays important roles
in regulating viral infection and replication. To address the relationship of influenza A virus …

The pivotal roles of neddylation pathway in immunoregulation

Y Lu, X Yang - Immunity, Inflammation and Disease, 2020 - Wiley Online Library
Introduction Protein neddylation, one of the most important posttranslational modifications
that tagging neuronal precursor cell‐expressed developmentally downregulated protein 8 …

Host-directed therapy against mycobacterium tuberculosis infections with diabetes mellitus

L Zhao, K Fan, X Sun, W Li, F Qin, L Shi, F Gao… - Frontiers in …, 2024 - frontiersin.org
Tuberculosis (TB) is caused by the bacterial pathogen Mycobacterium tuberculosis (MTB)
and is one of the principal reasons for mortality and morbidity worldwide. Currently …

Potassium ion channel Kir2.1 negatively regulates protective responses to Mycobacterium bovis BCG

V Sinha, A Singh, A Singh… - Journal of Leukocyte …, 2024 - academic.oup.com
Tuberculosis caused by the pathogen Mycobacterium tuberculosis leads to increased
mortality and morbidity worldwide. The prevalence of highly drug-resistant strains has …