Microtubules are non-covalent mesoscale polymers central to the eukaryotic cytoskeleton.
Microtubule structure, dynamics, and mechanics are modulated by a cell's choice of tubulin …

Tumor metastasis is a multistep process by which tumor cells disseminate from their primary
site and form secondary tumors at a distant site. Metastasis occurs through a series of steps …

Simple Summary Cell migration is an essential process from embryogenesis to cell death.
This is tightly regulated by numerous proteins that help in proper functioning of the cell. In …

Simple Summary The epithelial to mesenchymal transition (EMT) is a well-documented
process in the study of cancer metastases. The cytoskeleton is an intricate network involved …

Reversible detyrosination of α-tubulin is crucial to microtubule dynamics and functions, and
defects have been implicated in cancer, brain disorganization, and cardiomyopathies. The …

Microtubules are highly dynamic structures, which consist of α-and β-tubulin heterodimers,
and are involved in cell movement, intracellular trafficking, and mitosis. In the context of …

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

Epithelial-Mesenchymal Transition (EMT) is a critical process in embryonic development in
which epithelial cells undergo a transdifferentiation into mesenchymal cells. This process is …

Tubulin tyrosine ligase (TTL) catalyzes the post-translational retyrosination of detyrosinated
α-tubulin. Despite the indispensable role of TTL in cell and organism development, its …

Metastatic cases of breast cancer pose the primary challenge in clinical management of this
disease, demanding the identification of effective therapeutic strategies that remain wanting …