Hypoxia inducible factor 2α promotes tolerogenic macrophage development during cardiac transplantation through transcriptional regulation of colony stimulating …

M DeBerge, S Schroth, F Du, XY Yeap… - Proceedings of the …, 2024 - National Acad Sciences
Solid organ transplantation mobilizes myeloid cells, including monocytes and macrophages,
which are central protagonists of allograft rejection. However, myeloid cells can also be …

[HTML][HTML] AXL inhibition suppresses early allograft monocyte-to-macrophage differentiation and prolongs allograft survival

CZ Jordan, M Tunbridge, I Husain, H Kitai, ME Dilts… - JCI insight, 2024 - ncbi.nlm.nih.gov
Innate immune cells are important in the initiation and potentiation of alloimmunity in
transplantation. Immediately upon organ anastomosis and reperfusion, recipient monocytes …

Innate Immune Responses in Transplant Immunity

JM Ladowski, X Luo - Current Transplantation Reports, 2023 - Springer
Abstract Purpose of Review Despite a significant decrease in the rate of acute rejection, long-
term solid organ allotransplant success is limited by chronic rejection. Transplant research …

Alloantigen Infusion Activates the Transcriptome of Type 2 Conventional Dendritic Cells

SL Schroth, RTL Jones, EB Thorp - ImmunoHorizons, 2023 - journals.aai.org
Recent studies have revealed novel molecular mechanisms by which innate monocytic cells
acutely recognize and respond to alloantigen with significance to allograft rejection and …

Prognostic Value of Soluble AXL in Serum from Heart Failure Patients with Preserved and Reduced Left Ventricular Ejection Fraction

H Cristóbal, C Enjuanes, M Batlle, M Tajes… - Journal of Personalized …, 2023 - mdpi.com
Heart failure (HF) is classified according to the degree of reduction in left ventricular ejection
fraction (EF) in HF with reduced, mildly reduced, and preserved EF. Biomarkers could …

Noninvasive methods to reduce cardiac complications postheart transplant

L Zhou, A Wolfson, AS Vaidya - Current Opinion in Organ …, 2022 - journals.lww.com
Noninvasive imaging and biomarker testing continue to show promise as alternatives to
invasive testing for allograft rejection. Continued validation of their effectiveness may lead to …