SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic

A Bertoletti, N Le Bert, AT Tan - Immunity, 2022 - cell.com
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, multiple severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with increasing ability to …

Adaptive immune responses and immunity to SARS-CoV-2

D Primorac, K Vrdoljak, P Brlek, E Pavelić… - Frontiers in …, 2022 - frontiersin.org
Since the onset of the COVID-19 pandemic, the medical field has been forced to apply the
basic knowledge of immunology with the most up-to-date SARS-CoV-2 findings and …

SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+ and CD4+ T cells of broad specificity

JME Lim, AT Tan, N Le Bert, SK Hang… - Journal of Experimental …, 2022 - rupress.org
SARS-CoV-2 breakthrough infection in vaccinees induces virus-specific nasal-resident CD8+
and CD4+ T cells of broad specificity | Journal of Experimental Medicine | Rockefeller …

Short term, relative effectiveness of four doses versus three doses of BNT162b2 vaccine in people aged 60 years and older in Israel: retrospective, test negative, case …

S Gazit, Y Saciuk, G Perez, A Peretz, VE Pitzer… - bmj, 2022 - bmj.com
Objective To examine the relative effectiveness of a fourth dose of the Pfizer-BioNTech
mRNA (BNT162b2) vaccine compared with three vaccine doses over the span of 10 weeks …

Lower vaccine-acquired immunity in the elderly population following two-dose BNT162b2 vaccination is alleviated by a third vaccine dose

L Renia, YS Goh, A Rouers, N Le Bert, WN Chia… - Nature …, 2022 - nature.com
Understanding the impact of age on vaccinations is essential for the design and delivery of
vaccines against SARS-CoV-2. Here, we present findings from a comprehensive analysis of …

SARS-CoV-2 humoral and cellular immunity following different combinations of vaccination and breakthrough infection

J Pušnik, WO Monzon-Posadas, J Zorn… - Nature …, 2023 - nature.com
The elicited anti-SARS-CoV-2 immunity is becoming increasingly complex with individuals
receiving a different number of vaccine doses paired with or without recovery from …

Mucosal plasma cells are required to protect the upper airway and brain from infection

SA Wellford, AP Moseman, K Dao, KE Wright, A Chen… - Immunity, 2022 - cell.com
While blood antibodies mediate protective immunity in most organs, whether they protect
nasal surfaces in the upper airway is unclear. Using multiple viral infection models in mice …

Prior SARS-CoV-2 infection enhances and reshapes spike protein–specific memory induced by vaccination

V Barateau, L Peyrot, C Saade, B Pozzetto… - Science Translational …, 2023 - science.org
The diversity of vaccination modalities and infection history are both variables that have an
impact on the immune memory of individuals vaccinated against SARS-CoV-2. To gain more …

[HTML][HTML] Variations within the glycan shield of SARS-CoV-2 impact viral spike dynamics

ML Newby, CA Fogarty, JD Allen, J Butler… - Journal of Molecular …, 2023 - Elsevier
The emergence of SARS-CoV-2 variants alters the efficacy of existing immunity, whether
arisen naturally or through vaccination. Understanding the structure of the viral spike assists …

Defending against SARS-CoV-2: The T cell perspective

P Almendro-Vázquez, R Laguna-Goya… - Frontiers in …, 2023 - frontiersin.org
SARS-CoV-2-specific T cell response has been proven essential for viral clearance, COVID-
19 outcome and long-term memory. Impaired early T cell-driven immunity leads to a severe …