In recent years, microglia have been highlighted for playing integral roles in
neurodegenerative diseases, like glaucoma. To better understand the role of microglia …

Myeloid cells including microglia and macrophages play crucial roles in retinal homeostasis
by clearing cellular debris and regulating inflammation. These cells are activated in several …

Visual impairment is occasionally observed in multiple sclerosis (MS) and its animal model,
experimental autoimmune encephalomyelitis (EAE). Although uveitis and optic neuritis have …

Diabetic retinopathy (DR) affects about 200 million people worldwide, causing leakage of
blood components into retinal tissues, leading to activation of microglia, the resident …

Diabetic retinopathy, a microvascular disease characterized by irreparable vascular
damage, neurodegeneration and neuroinflammation, is a leading complication of diabetes …

Ischemic retinopathies including diabetic retinopathy are major causes of vision loss. Inner
blood-retinal barrier (BRB) breakdown with retinal vascular hyperpermeability results in …

Reactive microglia are a hallmark of age-related retinal degenerative diseases including
age-related macular degeneration (AMD). These cells are capable of secreting neurotoxic …

Diabetic retinopathy (DR)-associated vision loss is a devastating disease affecting the
working-age population. Retinal pathology is due to leakage of serum components into …

Retinal neovascularization (RNV), a major cause of blindness, is usually treated with anti-
VEGF drugs. Despite successes, incomplete patient responses push for alternative …

The nuclear factor one (NFI) transcription factor genes Nfia, Nfib, and Nfix are all enriched in
late-stage retinal progenitor cells, and their loss has been shown to retain these progenitors …