Less is more: Antibiotics at the beginning of life
M Stocker, C Klingenberg, L Navér, V Nordberg… - Nature …, 2023 - nature.com
Antibiotic exposure at the beginning of life can lead to increased antimicrobial resistance
and perturbations of the developing microbiome. Early-life microbiome disruption increases …
and perturbations of the developing microbiome. Early-life microbiome disruption increases …
Culture-negative early-onset neonatal sepsis—at the crossroad between efficient sepsis care and antimicrobial stewardship
C Klingenberg, RF Kornelisse, G Buonocore… - Frontiers in …, 2018 - frontiersin.org
Sepsis is a leading cause of mortality and morbidity in neonates. Presenting clinical
symptoms are unspecific. Sensitivity and positive predictive value of biomarkers at onset of …
symptoms are unspecific. Sensitivity and positive predictive value of biomarkers at onset of …
Evaluation of the neonatal sequential organ failure assessment and mortality risk in preterm infants with late-onset infection
Importance Infection in neonates remains a substantial problem. Advances for this
population are hindered by the absence of a consensus definition for sepsis. In adults, the …
population are hindered by the absence of a consensus definition for sepsis. In adults, the …
Analysis of antibiotic exposure and early-onset neonatal sepsis in Europe, North America, and Australia
E Giannoni, V Dimopoulou, C Klingenberg… - JAMA Network …, 2022 - jamanetwork.com
Importance Appropriate use of antibiotics is life-saving in neonatal early-onset sepsis (EOS),
but overuse of antibiotics is associated with antimicrobial resistance and long-term adverse …
but overuse of antibiotics is associated with antimicrobial resistance and long-term adverse …
A neonatal sequential organ failure assessment score predicts mortality to late-onset sepsis in preterm very low birth weight infants
JL Wynn, RA Polin - Pediatric research, 2020 - nature.com
Background An operational definition of organ dysfunction applicable to neonates that
predicts mortality in the setting of infection is lacking. We determined the utility of an …
predicts mortality in the setting of infection is lacking. We determined the utility of an …
2.5 million annual deaths—Are neonates in low-and middle-income countries too small to be seen? A bottom-up overview on neonatal morbi-mortality
F Rosa-Mangeret, AC Benski, A Golaz, PZ Zala… - Tropical medicine and …, 2022 - mdpi.com
(1) Background: Every year, 2.5 million neonates die, mostly in low-and middle-income
countries (LMIC), in total disregard of their fundamental human rights. Many of these deaths …
countries (LMIC), in total disregard of their fundamental human rights. Many of these deaths …
Challenges in developing a consensus definition of neonatal sepsis
M McGovern, E Giannoni, H Kuester, MA Turner… - Pediatric …, 2020 - nature.com
Sepsis remains a leading cause of morbidity and mortality in the neonatal population, and at
present, there is no unified definition of neonatal sepsis. Existing consensus sepsis …
present, there is no unified definition of neonatal sepsis. Existing consensus sepsis …
Culture-confirmed neonatal bloodstream infections and meningitis in South Africa, 2014–19: a cross-sectional study
RC Mashau, ST Meiring, A Dramowski… - The Lancet Global …, 2022 - thelancet.com
Background Few population-level estimates of invasive neonatal infections have been
reported from sub-Saharan Africa. We estimated the national incidence risk, aetiology, and …
reported from sub-Saharan Africa. We estimated the national incidence risk, aetiology, and …
Neonatal sepsis
M Ershad, A Mostafa, M Dela Cruz… - Current emergency and …, 2019 - Springer
Abstract Purpose of Review Neonatal sepsis is a diagnosis made in infants less than 28
days of life and consists of a clinical syndrome that may include systemic signs of infection …
days of life and consists of a clinical syndrome that may include systemic signs of infection …