Protozoan diseases continue to be a worldwide social and economic health problem.
Increased drug resistance, emerging cross resistance, and lack of new drugs with novel …

Visceral Leishmaniasis (VL) is the most fatal form of disease leishmaniasis. To date, there
are no effective prophylactic measures and therapeutics available against VL. Recently, new …

Trypanosoma cruzi, Trypanosoma brucei and Leishmania (Trypanosomatidae:
Kinetoplastida) are parasitic protozoan causing Chagas disease, African Trypanosomiasis …

Leishmaniasis is a tropical infectious disease caused by the protozoan Leishmania parasite.
The disease is transmitted by female sand flies and, depending on the infecting parasite …

Visceral leishmaniasis (VL), a vector-borne disease, is caused by an obligate
intramacrophage, kinetoplastid protozoan parasite of the genus Leishmania. Globally, VL is …

Despite advancements in the areas of omics and chemoinformatics, potent novel
biotherapeutic molecules with new modes of actions are needed for leishmaniasis. The …

Background Genetically modified mice are used widely to explore mechanisms in most
biomedical fields—including transfusion. Concluding that a gene modification is responsible …

Aim Leishmania donovani, the causative agent for visceral leishmaniasis (VL), modulates
host monocytes/macrophages to ensure its survival. However, knowledge regarding the host …

Leishmaniasis is a spectrum of diseases transmitted by sand fly vectors that deposit
Leishmania spp. parasites in the host skin during blood feeding. Currently, available …

Leishmaniasis, a disease of global relevance, results from infection with the protozoan
parasite, Leishmania, which is transmitted to susceptible hosts through the bite of sand flies …