Structural mechanisms of NLRP3 inflammasome assembly and activation
As an important sensor in the innate immune system, NLRP3 detects exogenous pathogenic
invasions and endogenous cellular damage and responds by forming the NLRP3 …
invasions and endogenous cellular damage and responds by forming the NLRP3 …
Role of pyroptosis in cardiovascular disease
Z Zhaolin, L Guohua, W Shiyuan, W Zuo - Cell proliferation, 2019 - Wiley Online Library
Cardiac function is determined by the dynamic equilibrium of various cell types and the
extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially …
extracellular matrix that composes the heart. Cardiovascular diseases (CVDs), especially …
[HTML][HTML] NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
Inflammasomes are intracellular protein complexes that drive the activation of inflammatory
caspases. So far, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have …
caspases. So far, four inflammasomes involving NLRP1, NLRP3, NLRC4 and AIM2 have …
A genome-wide CRISPR (clustered regularly interspaced short palindromic repeats) screen identifies NEK7 as an essential component of NLRP3 inflammasome …
JL Schmid-Burgk, D Chauhan, T Schmidt… - Journal of Biological …, 2016 - ASBMB
Inflammasomes are high molecular weight protein complexes that assemble in the cytosol
upon pathogen encounter. This results in caspase-1-dependent pro-inflammatory cytokine …
upon pathogen encounter. This results in caspase-1-dependent pro-inflammatory cytokine …
[HTML][HTML] NEK1 variants confer susceptibility to amyotrophic lateral sclerosis
KP Kenna, PTC Van Doormaal, AM Dekker, N Ticozzi… - Nature …, 2016 - nature.com
To identify genetic factors contributing to amyotrophic lateral sclerosis (ALS), we conducted
whole-exome analyses of 1,022 index familial ALS (FALS) cases and 7,315 controls. In a …
whole-exome analyses of 1,022 index familial ALS (FALS) cases and 7,315 controls. In a …
Mitotic regulation by NEK kinase networks
Genetic studies in yeast and Drosophila led to identification of cyclin-dependent kinases
(CDKs), Polo-like kinases (PLKs) and Aurora kinases as essential regulators of mitosis …
(CDKs), Polo-like kinases (PLKs) and Aurora kinases as essential regulators of mitosis …
NEK7: a potential therapy target for NLRP3-related diseases
G Liu, X Chen, Q Wang, L Yuan - Bioscience trends, 2020 - jstage.jst.go.jp
NLRP3 inflammasome plays an essential role in innate immunity, yet the activation
mechanism of NLRP3 inflammasome is not clear. In human or animal models, inappropriate …
mechanism of NLRP3 inflammasome is not clear. In human or animal models, inappropriate …
The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications
Amyotrophic lateral sclerosis is the most common degenerative disorder of motor neurons in
adults. As there is no cure, thousands of individuals who are alive at present will succumb to …
adults. As there is no cure, thousands of individuals who are alive at present will succumb to …
Conserved NIMA kinases regulate multiple steps of endocytic trafficking
Human NIMA-related kinases have primarily been studied for their roles in cell cycle
progression (NEK1/2/6/7/9), checkpoint–DNA-damage control (NEK1/2/4/5/10/11), and …
progression (NEK1/2/6/7/9), checkpoint–DNA-damage control (NEK1/2/4/5/10/11), and …
Physiological and pathological roles of mammalian NEK7
Z Sun, W Gong, Y Zhang, Z Jia - Frontiers in physiology, 2020 - frontiersin.org
NEK7 is the smallest NIMA-related kinase (NEK) in mammals. The pathological and
physiological roles of NEK7 have been widely reported in many studies. To date, the major …
physiological roles of NEK7 have been widely reported in many studies. To date, the major …