Macrophage phagocytosis after spinal cord injury: when friends become foes
After spinal cord injury, macrophages can exert either beneficial or detrimental effects
depending on their phenotype. Aside from their critical role in inflammatory responses …
depending on their phenotype. Aside from their critical role in inflammatory responses …
Role of the CD200-CD200R axis during homeostasis and neuroinflammation
Microglia are considered to be the resident macrophages of the CNS and main effector of
immune brain function. Due to their essential role in the regulation of neuroinflammatory …
immune brain function. Due to their essential role in the regulation of neuroinflammatory …
Neuroinflammation in Huntington's disease: From animal models to clinical therapeutics
Q Jia, S Li, XJ Li, P Yin - Frontiers in Immunology, 2022 - frontiersin.org
Huntington's disease (HD) is a progressive neurodegenerative disease characterized by
preferential loss of neurons in the striatum in patients, which leads to motor and cognitive …
preferential loss of neurons in the striatum in patients, which leads to motor and cognitive …
Microglial responses to brain injury and disease: functional diversity and new opportunities
As an integral part of the innate immune system of the brain, resident microglia must react
rapidly to the onset of brain injury and neurological disease. These dynamic cells then …
rapidly to the onset of brain injury and neurological disease. These dynamic cells then …
CD200: CD200R interactions and their importance in immunoregulation
K Kotwica-Mojzych, B Jodłowska-Jędrych… - International Journal of …, 2021 - mdpi.com
The molecule CD200, described many years ago as a naturally occurring
immunomodulatory agent, capable of regulating inflammation and transplant rejection, has …
immunomodulatory agent, capable of regulating inflammation and transplant rejection, has …
Excess administration of miR-340-5p ameliorates spinal cord injury-induced neuroinflammation and apoptosis by modulating the P38-MAPK signaling pathway
Spinal cord injury (SCI) is a destructive polyneuropathy that can result in loss of
sensorimotor function and sphincter dysfunction, and even death in critical situations …
sensorimotor function and sphincter dysfunction, and even death in critical situations …
The CD200/CD200R signaling pathway contributes to spontaneous functional recovery by enhancing synaptic plasticity after stroke
H Sun, X He, X Tao, T Hou, M Chen, M He… - Journal of …, 2020 - Springer
Background Spontaneous functional recovery occurs during the acute phase after stroke
onset, but this intrinsic recovery remains limited. Therefore, exploring the mechanism …
onset, but this intrinsic recovery remains limited. Therefore, exploring the mechanism …
Crosstalk between microglia and neurons in neurotrauma: an overview of the underlying mechanisms
Microglia are the resident immune cells of the brain and play a crucial role in housekeeping
and maintaining homeostasis of the brain microenvironment. Upon injury or disease …
and maintaining homeostasis of the brain microenvironment. Upon injury or disease …
Sodium butyrate exerts neuroprotective effects in spinal cord injury
M Lanza, M Campolo, G Casili, A Filippone… - Molecular …, 2019 - Springer
Sodium butyrate (SB) is a dietary microbial fermentation product and serves as an important
neuromodulator in the central nervous system. Recent experimental evidence has …
neuromodulator in the central nervous system. Recent experimental evidence has …
Ketone metabolite β-hydroxybutyrate ameliorates inflammation after spinal cord injury by inhibiting the NLRP3 inflammasome
G Kong, J Liu, R Li, J Lin, Z Huang, Z Yang, X Wu… - Neurochemical …, 2021 - Springer
Ketogenic diet (KD) has been shown to be beneficial in a range of neurological disorders,
with ketone metabolite β-hydroxybutyrate (βOHB) reported to block the nucleotide …
with ketone metabolite β-hydroxybutyrate (βOHB) reported to block the nucleotide …