Advancements in nose-to-brain drug targeting for Alzheimer's disease: a review of nanocarriers and clinical insights

K Komal, R Ghosh, D Sil, R Sharma, S Kumar… - …, 2025 - Springer
Alzheimer's disease (AD) is a type of neurodegenerative disease that describes cognitive
decline and memory loss resulting in disability in movement, memory, speech etc. Which first …

Exploring chitosan nanoparticles for enhanced therapy in neurological disorders: a comprehensive review

SA Vahab, A KI, VS Kumar - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Chitosan nanoparticles have emerged as a promising therapeutic platform for treating
neurological disorders due to their biocompatibility, biodegradability, and ease of …

Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals

SA Adscheid, AE Türeli… - Beilstein Journal of …, 2024 - beilstein-journals.org
Central nervous system diseases negatively affect patients and society. Providing successful
noninvasive treatments for these diseases is challenging because of the presence of the …

Drug delivery using gold nanoparticles

L Dykman, B Khlebtsov, N Khlebtsov - Advanced Drug Delivery Reviews, 2024 - Elsevier
Modern nanotechnologies provide various possibilities for efficiently delivering drugs to
biological targets. This review focuses on using functionalized gold nanoparticles (GNPs) as …

Potentiality of Marine Microbial Metabolites in the Remedy of Alzheimer's Disease: A Comprehensive Review

S Paul, M Dey, B Roy, B Dhara, AK Mitra - Proceedings of the Zoological …, 2024 - Springer
Alzheimer's disease (AD) is one of the most common neurodegenerative disorders that
leads to dementia among elderly. Formation of senile plaques in the brain by amyloid-β …

Targeting specific brain districts for advanced nanotherapies: A review from the perspective of precision nanomedicine

G Sierri, M Patrucco, D Ferrario… - Wiley …, 2024 - Wiley Online Library
Numerous studies are focused on nanoparticle penetration into the brain functionalizing
them with ligands useful to cross the blood–brain barrier. However, cell targeting is also …

Drop to Gate Nasal Drops Attenuates Sepsis‐Induced Cognitive Dysfunction

Y Zhuang, X Du, L Yang, Z Jiang, B Yu, W Gu, W Cui… - Small, 2024 - Wiley Online Library
Nasal administration can bypass the blood‐brain barrier and directly deliver drugs to the
brain, providing a non‐invasive route for central nervous system (CNS) diseases. Inspired …

[HTML][HTML] Nanoparticles composed of polysaccharide chitosan and oligosaccharide alginate for strengthen transdermal delivery of tacrolimus in atopic dermatitis

YA Huang, WJ Lin - Carbohydrate Polymer Technologies and Applications, 2025 - Elsevier
The transdermal delivery system was developed to overcome the side effect derived from
oral administration of tacrolimus in the treatment of atopic dermatitis (AD). The nanoparticles …

[HTML][HTML] Evolution of Alzheimer's Disease Therapeutics: From Conventional Drugs to Medicinal Plants, Immunotherapy, Microbiotherapy and Nanotherapy

E Ortiz-Islas, P Montes, CE Rodríguez-Pérez… - Pharmaceutics, 2025 - mdpi.com
Alzheimer's disease (AD) represents an escalating global health crisis, constituting the
leading cause of dementia among the elderly and profoundly impairing their quality of life …

Thermosensitive in-situ gel of Nifedipine: A strategy to offset cognition impairment in Alzheimer's disease

S Dighe, S Lonkar, S Jog, SV Mangrulkar… - Journal of Drug Delivery …, 2024 - Elsevier
Increased intracellular Ca 2+ accumulation plays a pivotal role in the development and
progression of Alzheimer's disease (AD). Thus, utilization of calcium channel blockers …