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Satellite DNA represents one of the most fascinating parts of the repetitive fraction of the
eukaryotic genome. Since the discovery of highly repetitive tandem DNA in the 1960s, a lot …

The human Y chromosome has been notoriously difficult to sequence and assemble
because of its complex repeat structure that includes long palindromes, tandem repeats and …

Genomic analyses of Neanderthals have previously provided insights into their population
history and relationship to modern humans 1, 2, 3, 4, 5, 6, 7, 8, but the social organization of …

Chromosomal aberrations including structural variations (SVs) are a major cause of human
genetic diseases. Their detection in clinical routine still relies on standard cytogenetics …

New normal linear modeling strategies are presented for analyzing read counts from RNA-
seq experiments. The voom method estimates the mean-variance relationship of the log …

The prevalence of highly repetitive sequences within the human Y chromosome has
prevented its complete assembly to date and led to its systematic omission from genomic …

The human Y chromosome harbors genes that are responsible for testis development and
also for initiation and maintenance of spermatogenesis in adulthood. The long arm of the Y …

CONTEXT: New data regarding the diagnosis and treatment of male infertility have emerged
and led to an update of the European Association of Urology (EAU) guidelines for Male …

The human X and Y chromosomes evolved from an ordinary pair of autosomes, but millions
of years ago genetic decay ravaged the Y chromosome, and only three per cent of its …