Globally, females are∼ 30% more likely to have pre-dialysis chronic kidney disease (CKD)
than males for reasons that are not fully understood. CKD is associated with numerous …

X-chromosomal genetic variants are understudied but can yield valuable insights into
sexually dimorphic human traits and diseases. We performed a sex-stratified cross-ancestry …

Kidney stone formation is an intricate process that involves a disruption in the interplay of the
multiple organs and systems involved in regulating the concentration of specific ions in the …

The kidney is considered to be one of the most estrogen-responsive, not reproductive
organs in the body. Different estrogen receptors (ERs) show sex-specific differences in …

Sex hormones influence excretion of the biopersistent per-and polyfluoroalkyl substances
(PFAS) in rodents, but such influences in human studies are less clear. Data from National …

Objective Menarche, as a milestone of puberty, may have a long-term effect on health. The
present study investigated the association of age at menarche with the incidence of arterial …

Women are more likely to be misdiagnosed and suffer the adverse effects of new
therapeutics compared to men. These types of findings were the impetus for mandates from …

Content The impact of endogenous estrogen exposure (EEE) on hypertension (HTN)
incidence has not been investigated yet. Objective This study aimed to evaluate HTN …

Context Chronic kidney disease (CKD) is a public health burden worldwide. Epidemiological
studies observed an association between sex hormones, including estradiol, and kidney …

Oxyresveratrol (OXY) is a naturally occurring phenolic compound; however, there are no
toxicity studies reported on its long term use. The aim of our work was to demonstrate the …