Psychological stress during childhood and adolescence increases risk of health problems
across the lifecourse, and inflammation is implicated as an underlying mechanism. To …

Depression onset peaks during adolescence and young adulthood. Current treatments are
only moderately effective, driving the search for novel pathophysiological mechanisms …

Importance Many studies have demonstrated an association between early-life adversity
(ELA) and executive functioning in children and adolescents. However, the aggregate …

Background In psychotic and mood disorders, immune alterations are hypothesized to
underlie cognitive symptoms, as they have been associated with elevated blood levels of …

Background Malfunctioning of executive functions correlates with psychopathology in
children. However, the directionality, the extent to which the relation varies for various …

Compelling evidence from animal and human research suggest a strong link between
inflammation and posttraumatic stress disorder (PTSD). Furthermore, recent findings support …

The overarching objective is to review how early exposure to adversity interacts with
inflammation to alter brain maturation. Both adversity and inflammation are significant risk …

Children exposed to adverse childhood experiences (ACEs) and pervasive interpersonal
traumas may go on to develop PTSD and, in most cases, will further undergo a significant …

Purpose Nowadays, the role of two tightly interconnected systems, the inflammatory
response system (IRS) and the compensatory immune response system (CIRS) in …

Background Evidence suggests that major depressive disorder is related to neuroaxonal
injury and that neurofilament light chain (NfL) is a biomarker of neuroaxonal injury. In …