Bestrophinopathy: an RPE-photoreceptor interface disease

KE Guziewicz, D Sinha, NM Gómez, K Zorych… - Progress in retinal and …, 2017 - Elsevier
Bestrophinopathies, one of the most common forms of inherited macular degenerations, are
caused by mutations in the BEST1 gene expressed in the retinal pigment epithelium (RPE) …

Lipofuscin, its origin, properties, and contribution to retinal fluorescence as a potential biomarker of oxidative damage to the retina

MB Różanowska - Antioxidants, 2023 - mdpi.com
Lipofuscin accumulates with age as intracellular fluorescent granules originating from
incomplete lysosomal digestion of phagocytosed and autophagocytosed material. The …

Label-free hyperspectral imaging and deep-learning prediction of retinal amyloid β-protein and phosphorylated tau

X Du, Y Koronyo, N Mirzaei, C Yang, DT Fuchs… - PNAS …, 2022 - academic.oup.com
Alzheimer's disease (AD) is a major risk for the aging population. The pathological hallmarks
of AD—an abnormal deposition of amyloid β-protein (Aβ) and phosphorylated tau (pTau) …

Hyperspectral imaging and the retina: worth the wave?

S Lemmens, J Van Eijgen, K Van Keer… - … vision science & …, 2020 - tvst.arvojournals.org
Purpose: Hyperspectral imaging is gaining attention in the biomedical field because it
generates additional spectral information to study physiological and clinical processes …

Hyperspectral autofluorescence imaging of drusen and retinal pigment epithelium in donor eyes with age-related macular degeneration

Y Tong, TB Ami, S Hong, R Heintzmann, G Gerig… - Retina, 2016 - journals.lww.com
Purpose: To elucidate the molecular pathogenesis of age-related macular degeneration
(AMD) and interpretation of fundus autofluorescence imaging, the authors identified spectral …

Hyperspectral imaging of the retina: a review

ER Reshef, JB Miller, DG Vavvas - International Ophthalmology …, 2020 - journals.lww.com
Hyperspectral imaging (HSI) is a form of spectral imaging pioneered for remote sensing
satellite imaging in agriculture and water control (Fig. 1). 1 HSI collects data from across the …

In situ morphologic and spectral characterization of retinal pigment epithelium organelles in mice using multicolor confocal fluorescence imaging

RK Meleppat, KE Ronning, SJ Karlen… - … & Visual Science, 2020 - iovs.arvojournals.org
Purpose: To investigate the major organelles of the retinal pigment epithelium (RPE) in wild-
type (WT, control) mice and their changes in pigmented Abca4 knockout (Abca4−/−) mice …

Fundus autofluorescence imaging in patients with choroidal melanoma

A Bindewald-Wittich, FG Holz, T Ach, M Fiorentzis… - Cancers, 2022 - mdpi.com
Simple Summary The ocular fundus contains molecules that emit fluorescence when excited
with light of an appropriate wavelength. Fundus autofluorescence imaging is based on the in …

Clinical applications of non‐invasive multi and hyperspectral imaging of cell and tissue autofluorescence beyond oncology

JM Campbell, SB Mahbub, A Habibalahi… - Journal of …, 2023 - Wiley Online Library
Hyperspectral and multispectral imaging of cell and tissue autofluorescence employs
fluorescence imaging, without exogenous fluorophores, across multiple excitation/emission …

Retinal organoids long-term functional characterization using two-photon fluorescence lifetime and hyperspectral microscopy

Y Xue, AW Browne, WC Tang, J Delgado… - Frontiers in Cellular …, 2021 - frontiersin.org
Pluripotent stem cell-derived organoid technologies have opened avenues to preclinical
basic science research, drug discovery, and transplantation therapy in organ systems. Stem …