Chronic caloric restriction (CR) has powerful anticarcinogenic actions in both preclinical and
clinical studies but may be difficult to sustain. As an alternative to CR, there has been …

The intestinal epithelium withstands continuous mechanical, chemical and biological insults
despite its single-layered, simple epithelial structure. The crypt–villus tissue architecture in …

Most animals alternate periods of feeding with periods of fasting often coinciding with sleep.
Upon> 24 hr of fasting, humans, rodents, and other mammals enter alternative metabolic …

Diet has a profound effect on tissue regeneration in diverse organisms, and low caloric
states such as intermittent fasting have beneficial effects on organismal health and age …

Metastasis consists of hallmark events, including Epithelial-Mesenchymal Transition (EMT),
angiogenesis, initiation of inflammatory tumor microenvironment, and malfunctions in …

The circadian rhythm is an evolutionarily conserved time-keeping system that comprises a
wide variety of processes including sleep–wake cycles, eating–fasting cycles, and activity …

Little is known about how metabolites couple tissue-specific stem cell function with
physiology. Here we show that, in the mammalian small intestine, the expression of Hmgcs2 …

Dietary interventions are potentially effective therapies for inflammatory bowel diseases
(IBDs). We tested the effect of 4-day fasting-mimicking diet (FMD) cycles on a chronic …

Acute kidney injury (AKI) exhibits high morbidity and mortality. Kidney injury molecule-1
(KIM1) is dramatically upregulated in renal tubules upon injury, and acts as a biomarker for …

For over a century, fasting regimens have improved health, lifespan and tissue regeneration
in diverse organisms, including humans,,,,–. However, how fasting and post-fast refeeding …