Natural product discovery: past, present, and future

L Katz, RH Baltz - Journal of Industrial Microbiology and …, 2016 - academic.oup.com
Microorganisms have provided abundant sources of natural products which have been
developed as commercial products for human medicine, animal health, and plant crop …

Gifted microbes for genome mining and natural product discovery

RH Baltz - Journal of Industrial Microbiology and Biotechnology, 2017 - academic.oup.com
Actinomycetes are historically important sources for secondary metabolites (SMs) with
applications in human medicine, animal health, and plant crop protection. It is now clear that …

Microbial genome mining for accelerated natural products discovery: is a renaissance in the making?

BO Bachmann, SG Van Lanen… - Journal of industrial …, 2014 - academic.oup.com
Microbial genome mining is a rapidly developing approach to discover new and novel
secondary metabolites for drug discovery. Many advances have been made in the past …

Natural product drug discovery in the genomic era: realities, conjectures, misconceptions, and opportunities

RH Baltz - Journal of Industrial Microbiology and Biotechnology, 2019 - academic.oup.com
Natural product discovery from microorganisms provided important sources for antibiotics,
anti-cancer agents, immune-modulators, anthelminthic agents, and insecticides during a …

Microbiome at the frontier of personalized medicine

PC Kashyap, N Chia, H Nelson, E Segal… - Mayo Clinic …, 2017 - Elsevier
The genomic revolution promises to transform our approach to treat patients by
individualizing treatments, reducing adverse events, and decreasing health care costs. The …

Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074

C Olano, I García, A González… - Microbial …, 2014 - Wiley Online Library
S treptomyces albus J 1074 is a streptomycete strain widely used as a host for expression of
secondary metabolite gene clusters. Bioinformatic analysis of the genome of this organism …

Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes

RH Baltz - Journal of Industrial Microbiology and Biotechnology, 2016 - academic.oup.com
Actinomycetes continue to be important sources for the discovery of secondary metabolites
for applications in human medicine, animal health, and crop protection. With the maturation …

Establishing a high yielding streptomyces‐based cell‐free protein synthesis system

J Li, H Wang, YC Kwon… - Biotechnology and …, 2017 - Wiley Online Library
Cell‐free protein synthesis (CFPS) has emerged as a powerful platform for applied
biotechnology and synthetic biology, with a range of applications in synthesizing proteins …

Anticancer activity of biostabilized selenium nanorods synthesized by Streptomyces bikiniensis strain Ess_amA-1

MS Ahmad, MM Yasser, EN Sholkamy… - International journal …, 2015 - Taylor & Francis
Selenium is an important component of human diet and a number of studies have declared
its chemopreventive and therapeutic properties against cancer. However, very limited …

Total in vitro biosynthesis of the nonribosomal macrolactone peptide valinomycin

L Zhuang, S Huang, WQ Liu, AS Karim, MC Jewett… - Metabolic …, 2020 - Elsevier
Natural products are important because of their significant pharmaceutical properties such
as antiviral, antimicrobial, and anticancer activity. Recent breakthroughs in DNA sequencing …