Background Diabetes has emerged as a major threat to health worldwide. Scope of Review
The exact mechanisms underlying the disease are unknown; however, there is growing …

The bioactive lipid sphingosine-1-phosphate (S1P) is involved in multiple cellular signalling
systems and has a pivotal role in the control of immune cell trafficking. As such, S1P has …

Inflammation is part of our body's response to tissue injury and pathogens. It helps to recruit
various immune cells to the site of inflammation and activates the production of mediators to …

Purpose: Sphingosine kinases (SK1 and SK2) regulate tumor growth by generating the
mitogenic and proinflammatory lipid sphingosine 1-phosphate (S1P). This phase I study …

The bioactive sphingolipids ceramide, sphingosine and sphingosine‐1‐phosphate (S1P)
are important signalling molecules that regulate a diverse array of cellular processes. Most …

During DNA replication, the enzyme telomerase maintains the ends of chromosomes, called
telomeres. Shortened telomeres trigger cell senescence, and cancer cells often have …

Sphingolipid metabolites, such as ceramide, sphingosine and sphingosine-1-phosphate
(S1P), play many important roles in cellular activities. Ceramide and sphingosine inhibit cell …

Simple Summary Cancer is the prime cause of death globally. The altered stimulation of
signaling pathways controlled by human kinases has often been observed in various human …

Disruption of sphingolipid homeostasis and signaling has been implicated in diabetes,
cancer, cardiometabolic, and neurodegenerative disorders. Yet, mechanisms governing …

The world is currently experiencing the worst health pandemic since the Spanish flu in 1918—
the COVID-19 pandemic—caused by the coronavirus severe acute respiratory syndrome …