Copper is an essential element in cells; it can act as either a recipient or a donor of
electrons, participating in various reactions. However, an excess of copper ions in cells is …

Copper-containing enzymes perform fundamental functions by activating dioxygen (O 2) and
therefore allowing chemical energy-transfer for aerobic metabolism. The copper …

Ionomics is a high-throughput elemental profiling approach to study the molecular
mechanistic basis underlying mineral nutrient and trace element composition (also known …

Mitochondrial cytochrome c oxidase (CcO) or respiratory chain complex IV is a heme aa 3-
copper oxygen reductase containing metal centers essential for holo-complex biogenesis …

The solute carrier (SLC) superfamily represents the biggest family of transporters with
important roles in health and disease. Despite being attractive and druggable targets, the …

Copper (Cu) is indispensible for growth and development of human organisms. It is required
for such fundamental and ubiquitous processes as respiration and protection against …

It has been more than 10 years since the concept of the ionome, all of the mineral nutrients
in a cell tissue or organism, was introduced. In the intervening years, ionomics, high …

Metal ions are potent catalysts and have been available for cellular biochemistry at all
stages of evolution. Growing evidence suggests that metal catalysis was critical for the origin …

Pancreatic cancer is a highly malignant tumour of the digestive tract which is difficult to
diagnose and treat. Approximately 90% of cases arise from ductal adenocarcinoma of the …

Brain development requires a fine-tuned copper homoeostasis. Copper deficiency or excess
results in severe neuro-pathologies. We demonstrate that upon neuronal differentiation …